Melatonina
Anno: 1999
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Riferimento:BMJ. 1999 Jan 23;318(7178):224-8.Azione della melatonina:Di Bella multitherapy did not show sufficient efficacy in patients with advanced cancer to warrant further clinical testing.Target:386 patients with advanced cancer were enrolled.
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Riferimento:Oncology. 1999;56(2):169-76.Azione della melatonina:Human breast cancer patients showed a decline in circulating melatonin levels.Target:Tryptophan 2,3-dioxygenase (TDO).
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Riferimento:BMJ. 1999 Jan 23;318(7178):224-8.Azione della melatonina:Di Bella multitherapy did not show sufficient efficacy in patients with advanced cancer to warrant further clinical testing.Target:Di Bella multitherapy.
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Riferimento:Neuro Endocrinol Lett. 1999;20(3-4):139-144.Azione della melatonina:Possible therapeutic significance of melatonin in neoplastic disease.Target:Alterations in melatonin concentrations
Anno: 2000
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Titolo: Influence of radiotherapy on 6-sulphatoxymelatonin levels in the urine of brain cancer patients.Riferimento:Neuro Endocrinol Lett. 2000;21(3):203-207.Azione della melatonina:Wide variation in the mean concentration of aMT6S excreted in the urine.Target:6-sulphatoxymelatonin
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Titolo: Growth-inhibitory activity of melatonin on human androgen-independent DU 145 prostate cancer cellsRiferimento:Prostate. 2000 Nov 1;45(3):238-44.Azione della melatonina:Melatonin exerts a direct oncostatic activity on human androgen-independent prostate cancer cells, and on breast cancer.Target:Mel nuclear receptors.
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Riferimento:Ann Epidemiol. 2000 Jan;10(1):31-44. Review.Azione della melatonina:EMF and light at night, might contribute to mammary carcinogenesis through inhibition of melatonin.Target:Electromagnetic fields (EMF).
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Riferimento:Epidemiology. 2000 Nov;11(6):660-5.Azione della melatonina:Alcoholic beverages may suppress circulating melatonin levels, and an incrising circulating estrogen could increase the risk of breast cancer.Target:6-sulfatoxymelatonin
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Riferimento:J Pineal Res. 2000 Jan;28(1):41-7.Azione della melatonina:The inclusion of morning urine widespread testing of the role played by melatonin in human health and disease.Target:6-hydroxymelatonin-sulfate (6-OHMS).
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Titolo: Melatonin effects on intercellular junctional communication in MCF-7 human breast cancer cellsRiferimento:J Pineal Res. 2000 Oct;29(3):166-71.Azione della melatonina:Melatonin (10 microM) could exert its antitumor action by increasing regulatory signals that are passed between adjacent epithelial cells through intercellular junctions.Target:Gap junctional intercellular communication.