Melatonina
Anno: 2009
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Riferimento:Postepy Hig Med Dosw (Online). 2009 Sep 15;63:425-34.Azione della melatonina:MT1 melatonin receptors benefits the efficacy of melatonin treatment.Target:MT1 (Mel1a) and MT2 (Mel1b) receptors.
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Riferimento:Cancer Lett. 2009 Aug 18;281(1):1-7.Azione della melatonina:In breast cancer risk, melatonin may also block the estrogen receptor ERalpha and impact the enzyme aromatase, which produces estradiol.Target:Estrogen receptor Eralpha Enzyme aromatase.
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Riferimento:Ann N Y Acad Sci. 2009 Aug;1171:345-9.Azione della melatonina:Stimulate reactive oxygen species (ROS).Target:EBV inhibits melatonin anti-apoptotic effects.
Anno: 2010
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Titolo: [Shift work and breast cancer]Riferimento:G Ital Med Lav Ergon. 2010 Oct-Dec;32(4):454-7.Azione della melatonina:Internal disruption of biological circadian rhythms and clock genes, melatonin suppression through light by night, sleep deprivation and breast cancer risk in women shift workers.Target:LAN
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Riferimento:J Pineal Res. 2010 Oct;49(3):210-21.Azione della melatonina:At a dosage of 25 mg/kg/day, S23478-1 is more efficacious than melatonin at inducing regression in rat mammary tumors.Target:MT1/MT2 melatonin receptor agonists,S23478-1.
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Riferimento:Steroids. 2010 Dec;75(12):944-51.Azione della melatonina:Physiologic concentrations of MLT inhibit the individual and combined transcriptional activity of ERalpha by RORalpha1 and E(2).Target:RORalpha1/E(2).
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Riferimento:Curr Cancer Drug Targets. 2010 May;10(3):279-86.Azione della melatonina:Mlt counteracted the stimulatory effects of estrone sulfate and exert its antitumoral effects by down-re-gulating the sulfatase pathway of the tumoral tissue.Target:Sulfatase-inhibitory properties of melatonin.
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):729-37.Azione della melatonina:Positive association between 6-sulphatoxymelatonin (aMT6s) and risk of breast cancer.Target:aMT6s
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Titolo: Global breast cancer seasonalityRiferimento:Breast Cancer Res Treat. 2010 Aug;123(1):233-43.Azione della melatonina:Breast cancer is consistently diagnosed more often in spring. Its mechanism may depend upon seasonal sunlight mediation of vitamin D and seasonal mediation of nocturnal melatonin peak level and duration.Target:Latitude-dependent breast cancer seasonality.
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Riferimento:J Pineal Res. 2010 Oct;49(3):283-90.Azione della melatonina:Inhibited DNA damage-induced apoptosis and glutathione (GSH) depletion.Target:TNF-α, TRAIL, anti-Fas antibody or endoplasmic reticulum (ER).