Melatonina
Anno: 2011
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Riferimento:J Pineal Res. 2011 Oct;51(3):345-52.Azione della melatonina:MLT may modulate miRNA and gene expression as an anticancer mechanism in MCF-7 human breast cancer cells.Target:MicroRNAs (miRNAs).
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Riferimento:J Pineal Res. 2011 Oct;51(3):259-69.Azione della melatonina:Down-regulation of 13-HODE reduces the activation of growth factor pathways supporting cell proliferation and survival.Target:3-hydroxyoctadecadie-noic acid (13-HODE).
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Riferimento:J Recept Signal Transduct Res. 2011 Apr;31(2):180-7.Azione della melatonina:The low expression of CYP1A1 or CYP1A2 in breast cancer specimens suggested that melatonin might be involved in cell cycle arrest.Target:CYP1A1/1A2, SULT1A1/1A3/1E1, cyclin D1.
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Riferimento:Med Pr. 2011;62(3):323-38.Azione della melatonina:A potential link between exposure to light at night and the risk of cancer, indicate that this type of work might lead to circadian disruption, including disruption in the melatonin synthesis.Target:Night shift work.
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Riferimento:J Biol Regul Homeost Agents. 2011 Oct-Dec;25(4):531-42.Azione della melatonina:Decreased expression of MT1 in human colorectal cancer could point to a role of melatonin in this disease.Target:Melatonin receptor 1 (MT1)
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Riferimento:J Pineal Res. 2011 Mar;50(2):150-8.Azione della melatonina:Cytostatic effects triggered by melatonin and D3 are likely related to a complex TGFβ-1-dependent mechanism, involving down-regulation of both MDM2 and Akt-phosphorylation.Target:p53/MDM2 ratio.
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Riferimento:World J Gastroenterol. 2011 Sep 14;17(34):3888-98.Azione della melatonina:Melatonin exerts its physiological effects through specific membrane receptors.Target:MT1, MT2 and MT3
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Riferimento:In Vivo. 2011 May-Jun;25(3):405-9.Azione della melatonina:Melatonin, 10(-5) M/10(-3) M, does not interfere with the cytotoxic effect of cytarabine, daunorubicin and etoposide in leukemia cells.Target:MLT/chemotherapeutic drugs.
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Riferimento:Biochem Biophys Res Commun. 2011 Feb 25;405(4):593-8.Azione della melatonina:MLT showed a great potential to control the preneo-plastic patterns induced by constant light (LL).Target:MLT-supplementation (10mg/kg/day).
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Riferimento:Oncogene advance online publication, 17 October 2011Azione della melatonina:Reduce the risks of developing cancer and preventing DNA damage.Target:Phosphorylation of p53 at Ser-15