Melatonina
Anno: 2011
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Riferimento:Breast Cancer Res Treat. 2011 May;127(1):91-8.Azione della melatonina:Abstract Mammary tumor growth is associated with old age and diminished levels of MLT and MT1 receptor during old age, resulting in reduced sensitivity to exogenous MLT.Target:MLT and its MT1 receptor.
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Riferimento:EPMA J. 2011 Dec;2(4):351-6.Azione della melatonina:Shift workers suffer from a disruption of the sleep-wake rhythm, insomnia and a lack of melatonin. These factors might trigger the development of breast cancer in female shift workers.Target:Shift work
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Riferimento:In Vivo. 2011 May-Jun;25(3):405-9.Azione della melatonina:Does not interfere with the cytotoxic effect of cytara-bine, daunorubicin and etoposide in leukemia cells.Target:10(-5) M and 10(-3) M concentrations of MLT.
Anno: 2012
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Riferimento:J Recept Signal Transduct Res. 2012 Dec;32(6):290-7.Azione della melatonina:EMR increase the risk of breast cancer suppressing the production of melatonin which may modulate breast cancer through enhanced oxidative stress and Ca(2+) influx in cell lines.Target:Electromagnetic radiation (EMR)
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Titolo: Melatonin suppresses aromatase expression and activity in breast cancer associated fibroblastsRiferimento:Breast Cancer Res Treat. 2012 Apr;132(2):765-71.Azione della melatonina:MLT inhibits estrogen production in breast adipose fibroblasts (BAFs) by inhibiting transcription of the CYP19A1 gene.Target:Physiological doses of MLT.
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Riferimento:Sleep Med Rev. 2012 Nov 5.Azione della melatonina:Melatonin suppression increased breast cancer risk, in night and rotating female shift workers.Target:Shift work
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Titolo: Melatonin interferes in the desmoplastic reaction in breast cancer by regulating cytokine productionRiferimento:J Pineal Res. 2012 Apr;52(3):282-90.Azione della melatonina:One millimolar melatonin induced a reduction in TNF-α, IL-6, and IL-11 mRNA expression in MCF-7 and 3T3-L1 cells.Target:Aromatase enzyme,tumor necrosis factor (TNF)-α, interleukin (IL)-11 and interleukin (IL)-6.
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Riferimento:Klin Onkol. 2012;25(5):359-63.Azione della melatonina:Melatonin ( 4 times a week,20 μg/ml of drinking water) significantly reduced tumor volume in comparison with control animals.Target:Chemoprevention
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Riferimento:J Pineal Res. 2012 Nov;53(4):366-73.Azione della melatonina:Melatonin could be a potential chemotherapeutic/preventive agent for malignant lymphocytes, where melatonin-induced apoptosis, melatonin can induce caspase activation independent from these receptors.Target:Anti-proliferative/pro-apoptotic effects.
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Riferimento:Breast Cancer Res Treat. 2012 Apr;132(2):693-9.Azione della melatonina:Genetic variation in the MTNR1a and 1b genes may contribute to breast cancer, no breast cancer associations were found for variants in the AANAT gene.Target:Mlt receptors 1a and 1b (MTNR1a and MTNR1b), arylalkylamine N-acetyl-transferase (AANAT).