Melatonina
Anno: 2012
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Riferimento:Am J Epidemiol. 2012 Nov 1;176(9):760-3.Azione della melatonina:Direct oncostatic properties of melatonin in shift-work-cancer association.Target:Night-shift work
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Riferimento:Cell Mol Life Sci. 2012 Sep 25.Azione della melatonina:Melatonin acts at different mechanisms of action, nvolving apoptosis activation, inhibition of proliferation, and cell differentiation.Target:Melatonin acts at different physiological levels.
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Riferimento:J Pineal Res. 2012 Aug 16.Azione della melatonina:Melatonin(1mm) play a role in the paracrine interactions between malignant epithelial cells and proximal endothelial cells through a downregulatory action on VEGF expression in human breast cancer cells, as well as decreasing tumoral angiogenesis.Target:Vascular endothelial growth factor (VEGF)
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Riferimento:J Pineal Res. 2012 Jan;52(1):12-20.Azione della melatonina:Mlt (1mM) could stimulate the differentiation of preadipocytes (3T3-L1) into adipocytes.Target:3T3-L1 adipocytes.
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Riferimento:Mol Endocrinol. 2012 Nov;26(11):1808-20.Azione della melatonina:Melatonin activates GSK3β by inhibiting epithelial-to-mesenchymal transition, a fundamental process underlying cancer metastasis.Target:Glycogen synthase kinase 3β (GSK3β)
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Riferimento:Breast Cancer (Auckl). 2012;6:137-50.Azione della melatonina:Melatonin administration following serum shock differentially suppressed or induced clock gene (Bmal1 and Per2) and CCG expression in MCF10A and MCF-7 cells.Target:Clock and clock-controlled genes (CCGs)
Anno: 2013
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Riferimento:BMC Cell Biol. 2013 Jan 7;14:1.Azione della melatonina:Melatonin enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.Target:DNA repair capacity
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Riferimento:Breast Cancer Res Treat. 2013 Feb;137(3):677-87.Azione della melatonina:Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.Target:TNBC