Melatonina

Target

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Azione della melatonina

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Anno: 2012

Titolo: Preclinical Efficacy of Melatonin to Reduce Methotrexate-Induced Oxidative Stress and Small Intestinal Damage in Rats

Riferimento:
Dig Dis Sci. 2012 Oct 10.

Azione della melatonina:
Supplementation by exogenous melatonin (20 and 40 mg/kg body weight) significantly reduces MTX-induced small intestinal damage.

Target:
Methotrexate (MTX).
Titolo: Correlation of the risk of breast cancer and disruption of the circadian rhythm (Review)

Riferimento:
Oncol Rep. 2012 Aug;28(2):418-28.

Azione della melatonina:
Circadian system alteration and melatonin reduction, for exposure to light-at-night during night shift work, is the most valid hypotheses on the relation of shift work and breast cancer.

Target:
Night shift work
Titolo: Breast Cancer Therapy Based on Melatonin

Riferimento:
Recent Pat Endocr Metab Immune Drug Discov. 2012 May;6(2):108-16. Review.

Azione della melatonina:
Based on its Selective Estrogen Receptor Modulator [SERM) and Selective Estrogen Enzyme Modulator (SEEM) properties. Its nocturnal suppression by light-at-night (LAN) has been considered a risk-factor for breast cancer.

Target:
Inhibiting activity of P450 aromatase.
Titolo: Sleep duration, spot urinary 6-sulfatoxymelatonin levels and risk of breast cancer among Chinese women in Singapore

Riferimento:
Int J Cancer. 2012 May 30.

Azione della melatonina:
Sleep duration is not significantly associated with breast cancer risk reduction.

Target:
6-sulfatoxymelatonin (aMT6s)
Titolo: Work at night and breast cancer - report on evidence-based options for preventive actions

Riferimento:
Scand J Work Environ Health. 2012 Jul 1;38(4):380-90.

Azione della melatonina:
Elevations in risk of breast cancer after about 20 years working night shift. Accelerated tumor growth by suppression of melatonin secretion.

Target:
Shift work carcinogenic to humans (group 2A).
Titolo: Combined effects of melatonin and all-trans retinoic acid and somatostatin on breast cancer cell proliferation and death: molecular basis for the anticancer effect of these molecules

Riferimento:
Eur J Pharmacol. 2012 Apr 15;681(1-3):34-43.

Azione della melatonina:
Administration of melatonin with all-trans retinoic acid and somatostatin may be of significant therapeutic benefit in breast cancer.

Target:
Melatonin effects potentiated

Anno: 2013

Titolo: Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathw

Riferimento:
BMC Cell Biol. 2013 Jan 7;14:1.

Azione della melatonina:
Melatonin enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.

Target:
DNA repair capacity
Titolo: Expression of melatonin receptors in triple negative breast cancer (TNBC) in African American and Caucasian women: relation to survival

Riferimento:
Breast Cancer Res Treat. 2013 Feb;137(3):677-87.

Azione della melatonina:
Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.

Target:
TNBC

A.I.A.N. - Modena

Melatonina

Anno: 2012

Anno: 2013

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