Melatonina
Anno: 2012
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Riferimento:Scand J Work Environ Health. 2012 Jul 1;38(4):380-90.Azione della melatonina:Elevations in risk of breast cancer after about 20 years working night shift. Accelerated tumor growth by suppression of melatonin secretion.Target:Shift work carcinogenic to humans (group 2A).
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Riferimento:Expert Opin Investig Drugs. 2012 Jun;21(6):819-31.Azione della melatonina:Melatonin could be an excellent adjuvant with the drugs currently used for breast cancer prevention.Target:Selective estrogen receptor/enzyme modulators
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Riferimento:J Pineal Res. 2012 Aug;53(1):77-90.Azione della melatonina:Inhibits cell proliferation and induces apoptosis in MDA-MB-361 breast cancer cells in vitro by simultaneously suppressing the COX-2/PGE2, p300/NF-κB and PI3K/Akt/signaling and activating the Apaf-1/ caspase-dependent apoptotic pathway.Target:Mlt 10(-3)M
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Riferimento:Mol Carcinog. 2012 Aug;51(8):608-18.Azione della melatonina:Melatonin inhibits growth and invasive capacity of colon cancer cells in vitro through its membrane (MT1 and MT2) and/or nuclear receptors (RORα).Target:MT1- MT2 - RORα
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2012 Apr;21(4):609-18.Azione della melatonina:Night shift work may disrupt the normal nocturnal rise in melatonin, resulting in increased breast cancer risk.Target:Reduced 6-sulfatoxymelatonin levels during night work and daytime sleep.
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Riferimento:BMJ Open. 2012 Jan 21;2(1).Azione della melatonina:Inverse relationship between aMTs-6(6-sulfatoxymelatonin) and oestradiol was suggested in the winter.Target:Long-term shift work as a probable carcinogen.
Anno: 2013
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Riferimento:BMC Cell Biol. 2013 Jan 7;14:1.Azione della melatonina:Melatonin enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.Target:DNA repair capacity
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Riferimento:Breast Cancer Res Treat. 2013 Feb;137(3):677-87.Azione della melatonina:Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.Target:TNBC