Melatonina

Target

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Azione della melatonina

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Anno: 2012

Titolo: [Neoplastic effect of indomethacin in N-methyl-N-nitrosourea induced mammary carcinogenesis in female rats]

Riferimento:
Klin Onkol. 2012;25(5):359-63.

Azione della melatonina:
Melatonin ( 4 times a week,20 μg/ml of drinking water) significantly reduced tumor volume in comparison with control animals.

Target:
Chemoprevention
Titolo: Melatonin inhibits cell proliferation and induces caspase activation and apoptosis in human malignant lymphoid cell lines

Riferimento:
J Pineal Res. 2012 Nov;53(4):366-73.

Azione della melatonina:
Melatonin could be a potential chemotherapeutic/preventive agent for malignant lymphocytes, where melatonin-induced apoptosis, melatonin can induce caspase activation independent from these receptors.

Target:
Anti-proliferative/pro-apoptotic effects.
Titolo: A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis

Riferimento:
Eur J Cancer Prev. 2012 Mar;21(2):163-70.

Azione della melatonina:
Resveratrol in combination with melatonin has some protective effects on N-methyl-N-nitrosourea (NMU)-induced rodent breast cancer.

Target:
Chemoprevention with resveratrol and mlt.
Titolo: Invited commentary: shift work and can

Riferimento:
Am J Epidemiol. 2012 Nov 1;176(9):760-3.

Azione della melatonina:
Direct oncostatic properties of melatonin in shift-work-cancer association.

Target:
Night-shift work
Titolo: Molecular mechanisms of melatonin's inhibitory actions on breast cancers

Riferimento:
Cell Mol Life Sci. 2012 Sep 25.

Azione della melatonina:
Melatonin acts at different mechanisms of action, nvolving apoptosis activation, inhibition of proliferation, and cell differentiation.

Target:
Melatonin acts at different physiological levels.
Titolo: Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells

Riferimento:
J Pineal Res. 2012 Aug 16.

Azione della melatonina:
Melatonin(1mm) play a role in the paracrine interactions between malignant epithelial cells and proximal endothelial cells through a downregulatory action on VEGF expression in human breast cancer cells, as well as decreasing tumoral angiogenesis.

Target:
Vascular endothelial growth factor (VEGF)

Anno: 2013

Titolo: Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathw

Riferimento:
BMC Cell Biol. 2013 Jan 7;14:1.

Azione della melatonina:
Melatonin enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.

Target:
DNA repair capacity
Titolo: Expression of melatonin receptors in triple negative breast cancer (TNBC) in African American and Caucasian women: relation to survival

Riferimento:
Breast Cancer Res Treat. 2013 Feb;137(3):677-87.

Azione della melatonina:
Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.

Target:
TNBC

A.I.A.N. - Modena

Melatonina

Anno: 2012

Anno: 2013

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