Melatonina

Target

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Azione della melatonina

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Anno: 2012

Titolo: Breast Cancer Therapy Based on Melatonin

Riferimento:
Recent Pat Endocr Metab Immune Drug Discov. 2012 May;6(2):108-16. Review.

Azione della melatonina:
Based on its Selective Estrogen Receptor Modulator [SERM) and Selective Estrogen Enzyme Modulator (SEEM) properties. Its nocturnal suppression by light-at-night (LAN) has been considered a risk-factor for breast cancer.

Target:
Inhibiting activity of P450 aromatase.
Titolo: Combined effects of melatonin and all-trans retinoic acid and somatostatin on breast cancer cell proliferation and death: molecular basis for the anticancer effect of these molecules

Riferimento:
Eur J Pharmacol. 2012 Apr 15;681(1-3):34-43.

Azione della melatonina:
Administration of melatonin with all-trans retinoic acid and somatostatin may be of significant therapeutic benefit in breast cancer.

Target:
Melatonin effects potentiated
Titolo: Work at night and breast cancer - report on evidence-based options for preventive actions

Riferimento:
Scand J Work Environ Health. 2012 Jul 1;38(4):380-90.

Azione della melatonina:
Elevations in risk of breast cancer after about 20 years working night shift. Accelerated tumor growth by suppression of melatonin secretion.

Target:
Shift work carcinogenic to humans (group 2A).
Titolo: Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation

Riferimento:
Expert Opin Investig Drugs. 2012 Jun;21(6):819-31.

Azione della melatonina:
Melatonin could be an excellent adjuvant with the drugs currently used for breast cancer prevention.

Target:
Selective estrogen receptor/enzyme modulators
Titolo: Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells

Riferimento:
J Pineal Res. 2012 Aug;53(1):77-90.

Azione della melatonina:
Inhibits cell proliferation and induces apoptosis in MDA-MB-361 breast cancer cells in vitro by simultaneously suppressing the COX-2/PGE2, p300/NF-κB and PI3K/Akt/signaling and activating the Apaf-1/ caspase-dependent apoptotic pathway.

Target:
Mlt 10(-3)M
Titolo: Gender-related invasion differences associated with mRNA expression levels of melatonin membrane receptors in colorectal cancer

Riferimento:
Mol Carcinog. 2012 Aug;51(8):608-18.

Azione della melatonina:
Melatonin inhibits growth and invasive capacity of colon cancer cells in vitro through its membrane (MT1 and MT2) and/or nuclear receptors (RORα).

Target:
MT1- MT2 - RORα

Anno: 2013

Titolo: Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathw

Riferimento:
BMC Cell Biol. 2013 Jan 7;14:1.

Azione della melatonina:
Melatonin enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.

Target:
DNA repair capacity
Titolo: Expression of melatonin receptors in triple negative breast cancer (TNBC) in African American and Caucasian women: relation to survival

Riferimento:
Breast Cancer Res Treat. 2013 Feb;137(3):677-87.

Azione della melatonina:
Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.

Target:
TNBC

A.I.A.N. - Modena

Melatonina

Anno: 2012

Anno: 2013

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