Melatonina
Anno: 1994
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Titolo: Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells.Riferimento:Mol Endocrinol. 1994 Dec;8(12):1681-90.Azione della melatonina:Antiproliferative actions of Mlt are mediated through the suppression of the transcription of ER gene.Target:Estrogen receptor (ER) mRNA
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Riferimento:Biol Signals. 1994 Nov-Dec;3(6):302-6.Azione della melatonina:Plasma melatonin concentrations in tumor-bearing rats killed at 3.00 h were suppressed by 35% when compared to the control animals killed at the same time.Target:Plasma melatonin concentrations
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Riferimento:Cancer Lett. 1994 Sep 30;85(1):105-9.Azione della melatonina:Antiproliferative effect was obtained by sequential exposure to 10(-9) M/10(-11)M 12/12h melatonin, which mimics the physiological rhythm of serum melatonin concentration.Target:Physiological rhythm/serum melatonin concentration
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Riferimento:J Pineal Res. 1994 Aug;17(1):25-32.Azione della melatonina:Melatonin(10(-9)M) may inhibit the action and/or release of growth stimulatory factors as well as stimulate the release of growth inhibitory factors.Target:Epidermal growth factor (EGF)
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Riferimento:J Natl Cancer Inst. 1994 Jun 15;86(12):921-5.Azione della melatonina:Exposure to extremely low-frequency electromagnetic fields reduces the production of melatonin.Target:ELF
Anno: 1995
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Titolo: Melatoni blocks the stimulatory effects of prolactin on human breast cancer cell growth in cultureRiferimento:Br J Cancer. 1995 Dec;72(6):1435-40.Azione della melatonina:Mlt interrupts the PRL receptor (PRLR)-mediated growth signal in HBC and suggest that the oncostatic activity of Mlt may also be linked with an antagonism of PRL's actions.Target:Monoclonal antibodies (Mabs) against PRLR
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Riferimento:Oncol Rep. 1995 Nov;2(6):1063-8.Azione della melatonina:Induce objective tumor regressions in most advanced solid tumor histotypes by low-dose IL-2 plus MLT (orally at 40 mg/day).Target:Interleukin-2 (IL.2)
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Riferimento:Anticancer Res. 1995 Nov-Dec;15(6B):2633-7.Azione della melatonina:Patients with multiple myeloma showed significantly higher mean melatonin serum levels, increased secretion might be considered as a compensatory mechanism of regulating neoplastic growth.Target:Antineoplastic activity.
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Titolo: The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytesRiferimento:J Biol Chem. 1995 Mar 31;270(13):7037-40.Azione della melatonina:Melatonin is a natural ligand of RZR alpha and RZR beta, down-regulating the expression of 5-lipoxygenase about 5-fold in B-Lymphocytes.Target:Retinoid Z receptor (RZR alpha and beta).
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Riferimento:Oncol Rep. 1995 Sep;2(5):871-3.Azione della melatonina:Association of MLT(20 mg/day orally) may make TMX effective also in ER-negative metastatic breast cancer patients.Target:Tamoxifen (TMX) Melatonin(MLT) Estrogen receptor (ER)