Neoplasie della mammella
Anno: 2002
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Riferimento:Breast Cancer Res Treat. 2002 Jan;71(1):37-45.Azione della melatonina:Melatonin pre-treatment ((10(-9)-10(-6) M) for 30 min) significantly reduced E2-induced ERalpha transactivation and Eralpha-ERE(estrogen response element) binding activity.Target:Estrogen receptor-alpha (ERalpha)
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Riferimento:Mol Cell Endocrinol. 2002 Jun 28;192(1-2):147-56.Azione della melatonina:Involvement of the MT(1) melatonin receptor in mediation of melatonin effects on growth-suppression and gene-modulation in breast cancer cells.Target:MT(1) receptor
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Riferimento:Epidemiology. 2002 Jan;13(1):116.Azione della melatonina:No abstract available.Target:No abstract available.
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Riferimento:J Pineal Res. 2002 Mar;32(2):90-6.Azione della melatonina:Melatonin (1nM) and dihydroxycholecalciferol (D3) (100 nM) reduce MCF-7 cell proliferation by modulating cell-cycle length through the control of the p53-p21 pathway.Target:D3/p53/p21
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Titolo: Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cellsRiferimento:J Pineal Res. 2002 Mar;32(2):112-9.Azione della melatonina:Melatonin (10(-7) M) effects on the Ca2+/CaM path-way play a role in the growth-inhibitory on MCF-7 human breast cancer cells.Target:(Ca2+)/calmodulin (CaM)
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Riferimento:Med Sci Monit. 2002 Jun;8(6):CR457-61.Azione della melatonina:A negative correlation between plasma melatonin and IGF-I concentrations in patients with neoplastic disease imply an additional defense mechanism based on the oncostatic influence of melatonin.Target:Insulin-like growth factor-I (IGF-I)
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Riferimento:Breast Cancer Res Treat. 2002 Mar;72(1):33-43.Azione della melatonina:Combination of Mlt and 9cRA could be a potentially useful clinical treatment regimen for breast cancer.Target:9-cis-retinoic acid (9cRA)
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Titolo: The trajectory of fatigue in adult patients with breast and ovarian cancer receiving chemotherapyRiferimento:Oncol Nurs Forum. 2002 Oct;29(9):1334-40.Azione della melatonina:Fatigue fluctuates during the course ofchemotherapy treatment and does not cease after treatment ends. Preliminary findings suggest that fatigue mechanisms may have an undetermined physiologic basis.Target:Fatigue mechanisms
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Riferimento:Obstet Gynecol Surv. 2002 May;57(5):314-23.Azione della melatonina:The reader will be able to summarize the effects of estrogen and progestogens on the breast and to list the effects of otherhormonal modulators on thebreast.Target:Hormones and antihormones
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Riferimento:Am J Clin Pathol. 2002 Sep;118(3):451-8.Azione della melatonina:MT1 receptors were detectable in normal and malignant breast epithelium, high receptor levels occurred more frequently in tumor cells.Target:MT1 receptor