Neoplasie della mammella
Anno: 2002
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Riferimento:J Natl Cancer Inst. 2002 Apr 3;94(7):531-2; author reply 533-4.Azione della melatonina:No abstract available.Target:No abstract available.
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Riferimento:Neuro Endocrinol Lett. 2002 Jul;23 Suppl 2:52-6.Azione della melatonina:Light exposure during darkness increases the risk of cancer progression via elimination of the nocturnal melatonin signal and its suppression of tumor LA uptake and metabolism to 13-HODE.Target:Linoleic Acid/13-hydro-xyoctadecadienoic acid
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Riferimento:Cancer Res. 2002 Mar 1;62(5):1356-63.Azione della melatonina:In contrast to the melatonin hypothesis, melatonin levels in pineal or mammary glands were not affected by MF exposure.Target:50-Hz magnetic fields (MFs)
Anno: 2003
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Riferimento:Epidemiology. 2003 Sep;14(5):514-20.Azione della melatonina:The results of this large investigation are consistent with those of most previous studies, and do not support the hypothesis that electric blanket use is associated with increased breast cancer risk.Target:EMF
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Riferimento:Breast Cancer Res Treat. 2003 Jun;79(3):313-20.Azione della melatonina:The first biological evidence for a potential link between constant light exposure and increased human breast oncogenesis involving MLT suppression and stimulation of tumor linoleic acid (LA)metabolism.Target:LAN/Linoleic Acid(LA)
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Riferimento:Crit Rev Oncol Hematol. 2003 Jun;46(3):221-34.Azione della melatonina:Pineal peptide preparation Epithalamin and synthetic tetrapeptide Epitalon (Ala-Glu-Asp-Gly) are potent inhibitors of mammary carcinogenesis in ro-dents and might be useful in the prevention of breast cancer in women at risk.Target:LAN
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Riferimento:Endocr Relat Cancer. 2003 Jun;10(2):153-9.Azione della melatonina:Melatonin (1 nM) down-regulates the expression of estrogen receptor (ERalpha) and inhibits the binding of the estradiol-ER complex to the estrogen response element (ERE) in the DNA.Target:Eralpha/ERE
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Riferimento:J Surg Res. 2003 Apr;110(2):332-7.Azione della melatonina:Combination therapy with 1,25-(OH)(2)-D(3) and MEL in the treatment of breast cancer suggest that the growth inhibition could be related to the enhanced TGF-beta(1) secretion.Target:Dihydroxyvitamin D(3) Transforming growth-factor beta 1
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Riferimento:J Natl Cancer Inst. 2003 Jun 4;95(11):825-8.Azione della melatonina:These data suggest that working a rotating night - shift at least three nights per month for 15 or more years may increase the risk of colorectal cancer in women.Target:LAN
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Riferimento:Cancer Lett. 2003 Jan 10;189(1):49-57.Azione della melatonina:In response to exogenous melatonin, tumor incidence in the mice receiving the MT1-overexpressing MCF-7 cells was decreased by 80% compared to mice receiving vector-transfected (vt-MCF-7) cells.Target:MT1 receptor