Neoplasie della mammella
Anno: 2007
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Riferimento:Scand J Work Environ Health. 2007 Oct;33(5):336-43.Azione della melatonina:No evidence was found for an association between shift work and breast or prostate cancer, or all cancer sites combined among shift workers.Target:Nighttime shift workers.
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Riferimento:Mol Cell Biochem. 2007 Jan;294(1-2):19-24.Azione della melatonina:Intense exercise-induced stress enhances mammary carcinogenesis through the involvement of adrenaline and prolactin, also confirmed a role of melatonin as a therapeutic aid against breast cancer in general.Target:"Anti-stress" role of Mlt.
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Riferimento:Prof Inferm. 2007 Apr-Jun;60(2):89-93.Azione della melatonina:Nurses who attend night shifts should undergo strict and periodical breast cancer screening, since the risk is significantly increased in this population.Target:Light-at-night
Anno: 2008
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Riferimento:G Ital Med Lav Ergon. 2008 Jul-Sep;30(3):276-9.Azione della melatonina:Shift-work has been associated with breast cancer, due to a circadian disruption and to a nocturnal suppression in melatonin production.Target:Shift-work.
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Titolo: Melatonin and estradiol effects on food intake, body weight, and leptin in ovariectomized ratsRiferimento:Maturitas. 2007 Sep 20;58(1):91-101.Azione della melatonina:In ovariectomized rats,melatonin reduced food intake and partially prevented the increase of body weight and cholesterol, without changing leptin levels.Target:Sulphatoxymelatonin (aMT6s).
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Riferimento:Br J Cancer. 2008 Nov 4;99(9):1502-5.Azione della melatonina:In a prospective study on Japanese women, short sleep duration was associated with higher risk of breast cancer.Target:LAN
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Riferimento:Breast Cancer Res Treat. 2008 Apr;108(3):339-50.Azione della melatonina:Melatonin,at physiological concentration,suppresses estrogen receptor(ER) gene, modulates several estrogen dependent regulatory proteins and pro-oncogenes, inhibits cell proliferation, and impairs the metastatic capacity of MCF-7 human breast cancer cells.Target:Estrogen receptor (ER)
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Riferimento:Aviat Space Environ Med. 2007 Apr;78(4 Suppl):A26-37.
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Riferimento:Integr Cancer Ther. 2008 Sep;7(3):189-203.Azione della melatonina:Melatonin's oncostatic actions include the direct augmentation of natural killer (NK) cell activity, which increases immunosurveillance, stimulation of cytokine production and protection on hematopoietic precursors from the toxic effect of anticancer chemotherapeutic drugs.Target:Immunomodulation, hematopoiesis, and antioxidative processes.
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Riferimento:Cancer Lett. 2008 Sep 18;268(2):272-7.Azione della melatonina:Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors.Target:HumanTelomerase ReverSeTranscriptase (hTERT)