Neoplasie della mammella
Anno: 2008
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Titolo: An indomethacin analogue...Riferimento:Biochem Pharmacol. 2008 Jan 15;75(2):484-93.Azione della melatonina:Identification of CBM as a specific inhibitor of AKR1C3 and the resultant effects on prostate and breast cancer cells.Target:N-(4-chlorobenzoyl)- melatonin (CBM)
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Riferimento:Curr Cancer Drug Targets. 2008 Dec;8(8):691-702.Azione della melatonina:Melatonin inhibits the growth of breast cancer by interacting with estrogen-signaling(SERM)-(SEEM) pathways.Target:Selective estrogen recetor modulator (SERM), selective estrogen enzyme modulator (SEEM).
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Riferimento:Eur J Cancer Prev. 2008 Oct;17(5):467-72.Azione della melatonina:Positive relationship between the sleep variation and E2 levels (60% lower) in women of reproductive age.Target:17-beta estradiol (E2)
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Titolo: Suppression of implanted MDA-MB 231 human breast cancer growth in nude mice by dietary walnutRiferimento:Nutr Cancer. 2008;60(5):666-74.Azione della melatonina:Tumor cell proliferation was decreased, but apoptosis was not altered due to walnut consumption.Target:Walnuts diet.
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Titolo: Melatonin and estradiol effects on food intake, body weight, and leptin in ovariectomized ratsRiferimento:Maturitas. 2007 Sep 20;58(1):91-101.Azione della melatonina:In ovariectomized rats,melatonin reduced food intake and partially prevented the increase of body weight and cholesterol, without changing leptin levels.Target:Sulphatoxymelatonin (aMT6s).
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Riferimento:G Ital Med Lav Ergon. 2008 Jul-Sep;30(3):276-9.Azione della melatonina:Shift-work has been associated with breast cancer, due to a circadian disruption and to a nocturnal suppression in melatonin production.Target:Shift-work.
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Riferimento:Br J Cancer. 2008 Nov 4;99(9):1502-5.Azione della melatonina:In a prospective study on Japanese women, short sleep duration was associated with higher risk of breast cancer.Target:LAN
Anno: 2009
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Riferimento:J Pineal Res. 2009 Aug;47(1):23-31.Azione della melatonina:Treatment of MCF-7 breast cancer cells with melatonin counteracted the increase induced by estradiol almost completely.Target:Membrane-bound receptor MT1.
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Riferimento:Breast Cancer Res Treat. 2009 Nov;118(2):293-305.Azione della melatonina:Amplification of the MT1gene in some breast tumors and an inverse correlation with ERalpha, PR and MT1 G protein-coupled melatonin receptor.Target:Estrogen receptor alpha (Eralpha), progesterone receptor (PR).
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Riferimento:Anticancer Agents Med Chem. 2009 Jun;9(5):500-16.Azione della melatonina:We should seriously consider alternative mechanisms such as melatonin or retinoic acid,that may be beneficial to patients' well being.Target:Increasing survival and patients' quality of life.