Neoplasie della mammella
Anno: 2009
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Riferimento:J Pineal Res. 2009 Mar;46(2):172-80.Azione della melatonina:Two distinct apoptotic processes are triggered by melatonin(1 nM), an early, TGFbeta1 and caspase-independent response, and a late TGFbeta1-dependent process in which activated-caspase-7.Target:Transforming growth factor beta 1 (TGFbeta1)
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Riferimento:Integr Cancer Ther. 2009 Dec;8(4):347-53.Azione della melatonina:Melatonin's anticancer effects in vivo involves inhibition of linoleic acid(LA)uptake and its metabolism to mitogenically active 13-hydroxyoctadecadienoic acid (13-HODE).Target:LA 13-HODE
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Titolo: Urinary melatonin levels and postmenopausal breast cancer risk in the Nurses' Health Study cohortRiferimento:Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):74-9.Azione della melatonina:An increased concentration of urinary aMT6s was associated with a lower risk of breast cancer.Target:6-sulfatoxymelatonin (aMT6s).
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Titolo: Circadian clock manipulation for cancer prevention and control and the relief of cancer symptomsRiferimento:Integr Cancer Ther. 2009 Dec;8(4):387-97.Azione della melatonina:Single nucleotide polymorphisms within the genes of clock, clock-controlled, and melatonin pathways have been found to confer excess cancer risk or protection from cancer.Target:Per2 and Per1
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Riferimento:Sleep Med Rev. 2009 Aug;13(4):257-64.Azione della melatonina:Studies suggest that a shortened duration of nocturnal sleep,circadian phase shifts, nocturnal melatonin suppression are associated with a higher risk of breast cancer development.Target:LAN
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Riferimento:Cancer Lett. 2009 Aug 18;281(1):1-7.Azione della melatonina:In breast cancer risk, melatonin may also block the estrogen receptor ERalpha and impact the enzyme aromatase, which produces estradiol.Target:Estrogen receptor Eralpha Enzyme aromatase.
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Riferimento:Postepy Hig Med Dosw (Online). 2009 Sep 15;63:425-34.Azione della melatonina:MT1 melatonin receptors benefits the efficacy of melatonin treatment.Target:MT1 (Mel1a) and MT2 (Mel1b) receptors.
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Riferimento:J Pineal Res. 2009 Jan;46(1):115-6.Azione della melatonina:No abstract available.Target:No abstract available.
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Riferimento:Br J Cancer. 2009 Nov 3;101(9):1613-9.Azione della melatonina:Melatonin(1nM)inhibits aromatase activity and expression by regulating the gene expression of specific aromatase promote region pI.4, and inhibit COX-2 and COX-1 mRNA expression.Target:COX-2/COX-1 mRNA expression.
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Riferimento:Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.Azione della melatonina:N(4-chlorobenzoyl)melatonin as a specific AKR1C3 inhibitor validate its role in the proliferation of breast cancer cells.Target:Aldo-keto reductase (AKR) 1C3