Neoplasie della mammella
Anno: 2009
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Titolo: Defining chronodisruptionRiferimento:J Pineal Res. 2009 Apr;46(3):245-7.Azione della melatonina:Melatonin being a key biological intermediary, via circadian disruption with epidemic cancers such as of the breast or prostate.Target:Chronodisruption (CD)
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Riferimento:Expert Rev Mol Med. 2009 Feb 5;11:e5.Azione della melatonina:Potential use of melatonin in breast cancer prevention and treatment.Target:Oestrogen-dependent, free-radical formation.
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Riferimento:Breast Cancer Res Treat. 2009 May;115(1):13-27.Azione della melatonina:The oncostatic properties of melatonin as they involve epigenetic mechanisms of cancer are reviewed.Target:Eralpha, aromatase, CYP19 histones,cyclin D1 LAN, PER2.
Anno: 2010
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Riferimento:Cell Cycle. 2010 Jan 1;9(1):188-97.Azione della melatonina:The combined treatment with metformin + melatoni (2 mg/L in drinking water during the night time) significantly suppressed Ehrlich tumor growth.Target:Biguanide metformin.
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Riferimento:Breast Cancer Res. 2010;12(6):R107.Azione della melatonina:Mlt (10-9M) exerts an inhibitory effect on breast cancer cell invasion through down-regulation of the p38, and inhibition of MMP-2 and MMP-9.Target:Proteinase activity of MMP-2 and MMP-9.
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Riferimento:Bioelectromagnetics. 2010 Apr;31(3):237-45.Azione della melatonina:In breast cancer cells transfected with MT1 exposed to 1.2 microT of the 50 Hz EMF, the expression of p53 and c-myc increased significantly after melatonin treatment.Target:Electromagnetic fields (EMFs)
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Titolo: [Shift work and breast cancer]Riferimento:G Ital Med Lav Ergon. 2010 Oct-Dec;32(4):454-7.Azione della melatonina:Internal disruption of biological circadian rhythms and clock genes, melatonin suppression through light by night, sleep deprivation and breast cancer risk in women shift workers.Target:LAN
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Riferimento:J Pineal Res. 2010 Oct;49(3):210-21.Azione della melatonina:At a dosage of 25 mg/kg/day, S23478-1 is more efficacious than melatonin at inducing regression in rat mammary tumors.Target:MT1/MT2 melatonin receptor agonists,S23478-1.
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Riferimento:Steroids. 2010 Dec;75(12):944-51.Azione della melatonina:Physiologic concentrations of MLT inhibit the individual and combined transcriptional activity of ERalpha by RORalpha1 and E(2).Target:RORalpha1/E(2).
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Riferimento:Curr Cancer Drug Targets. 2010 May;10(3):279-86.Azione della melatonina:Mlt counteracted the stimulatory effects of estrone sulfate and exert its antitumoral effects by down-re-gulating the sulfatase pathway of the tumoral tissue.Target:Sulfatase-inhibitory properties of melatonin.