Neoplasie della mammella
Anno: 1994
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Riferimento:Cancer Lett. 1994 Sep 30;85(1):105-9.Azione della melatonina:Antiproliferative effect was obtained by sequential exposure to 10(-9) M/10(-11)M 12/12h melatonin, which mimics the physiological rhythm of serum melatonin concentration.Target:Physiological rhythm/serum melatonin concentration
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Riferimento:J Pineal Res. 1994 Aug;17(1):25-32.Azione della melatonina:Melatonin(10(-9)M) may inhibit the action and/or release of growth stimulatory factors as well as stimulate the release of growth inhibitory factors.Target:Epidermal growth factor (EGF)
Anno: 1995
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Riferimento:Carcinogenesis. 1995 Dec;16(12):2945-9.Azione della melatonina:Oncostatic action of melatonin[10(-10) M]is exerted through modulation of the levels of gap junctional intercellular communication. Also, the data indicate that ELF-MF could counteract the melatonin-induced enhancement of junctional transfer.Target:Extremely low frequency (ELF magnetic fields(MF)
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Titolo: Melatoni blocks the stimulatory effects of prolactin on human breast cancer cell growth in cultureRiferimento:Br J Cancer. 1995 Dec;72(6):1435-40.Azione della melatonina:Mlt interrupts the PRL receptor (PRLR)-mediated growth signal in HBC and suggest that the oncostatic activity of Mlt may also be linked with an antagonism of PRL's actions.Target:Monoclonal antibodies (Mabs) against PRLR
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Riferimento:Oncol Rep. 1995 Nov;2(6):1063-8.Azione della melatonina:Induce objective tumor regressions in most advanced solid tumor histotypes by low-dose IL-2 plus MLT (orally at 40 mg/day).Target:Interleukin-2 (IL.2)
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Riferimento:Oncol Rep. 1995 Sep;2(5):871-3.Azione della melatonina:Association of MLT(20 mg/day orally) may make TMX effective also in ER-negative metastatic breast cancer patients.Target:Tamoxifen (TMX) Melatonin(MLT) Estrogen receptor (ER)
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Riferimento:Cancer Lett. 1995 Jul 13;93(2):207-12.Azione della melatonina:Direct relation between proliferative rate of cells and melatonin (10(-9)M) actions on MCF-7 cells.Target:Inhibitory actions on cell growth
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Riferimento:Oncology. 1995 Jul-Aug;52(4):278-83.Azione della melatonina:Clear stimulation of the immune system and Mlt at early but inhibition at advanced stages of cancer.Target:Mlt and cellular immunity
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Riferimento:Br J Cancer. 1995 Apr;71(4):854-6.Azione della melatonina:Concomitant administration of MLT (os,20mg/day) may induce tumour regressions in metastatic breast cancer patients refractory to TMX alone.Target:Melatonin (MLT) Tamoxifen (TMX)
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Titolo: The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytesRiferimento:J Biol Chem. 1995 Mar 31;270(13):7037-40.Azione della melatonina:5-lipoxygenase is the natural RZR alpha responding gene.New perspective in the involvement of MLT in inflammatory and immunological reactions.Target:Retinoid Z receptor (RZR alpha and beta)