ABSTRACT
Bilateral insufficiency fractures of the proximal femur often have a pathological basis. Diagnosis of rare causes of insufficiency fractures can be challenging. Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of mesenchymal tumours which leads to hypophosphataemia and osteomalacia. Suspected pathological fractures should be investigated thoroughly including a fasting serum phosphate level. Further investigations should include serum levels of fibroblast growth factor 23 (FGF23) which is a peptide hormone secreted by mesenchymal tumours. Available imaging modalities include Octreotide scanning which detects somatostatin receptors commonly expressed on mesenchymal tumours. After localisation and resection of the tumour, a full recovery from TIO is achievable.
Bilateral subtrochanteric fractures in tumour-induced osteomalacia caused by a nasal haemangiopericytoma
Riferimento:
Hip Int. 2012 Mar-Apr;22(2):227-9.
Autori:
Burnand H, Samuels A, Hagan I, Sawant N, Mutimer J.
Fonte:
Hip Int. 2012 Mar-Apr;22(2):227-9.
Anno:
2012
Azione:
Le modalità di imaging disponibili includono la scansione con Octreotide rilevante i recettori della somatostatina, comunemente espressi nell'osteomalacia mesenchimale neoplastica (TIO).
Target:
Octreotide/osteomalacia mesenchimale neoplastica.
Sostanze: