ABSTRACT
The management of neuroendocrine tumours is challenging when curative surgery is ruled out because of distant metastases. We report a case of gastrointestinal carcinoid with bilateral ovarian metastases in a 50-year-old female who received octreotide therapy followed by peptide receptor radionuclide therapy and surgery thereafter. Somatostatin receptor expression on neuroendocrine tumours has implications in diagnosis and therapy. (68)Ga-DOTA-NOC PET is a recent advancement in the field of somatostatin receptor imaging. The lesions which demonstrate tracer uptake on positron emission tomographic studies can be further planned for treatment with octreotide and (177)Lu-DOTA-TATE. The case in discussion responded well to non-invasive treatment options before proceeding to definitive surgical management.
Free Article
68Ga-DOTA-NOC PET and peptide receptor radionuclide therapy in management of bilateral ovarian metastases from gastrointestinal carcinoid
Riferimento:
Jpn J Clin Oncol. 2012 Dec;42(12):1202-6.
Autori:
Singla S, Gupta S, Reddy RM, Durgapal P, Bal CS.
Fonte:
Jpn J Clin Oncol. 2012 Dec;42(12):1202-6.
Anno:
2012
Azione:
(68)Ga-DOTA-NOC PET è un recente progresso nel campo dell'imaging dei recettori della somatostatina, usato in un caso di carcinoide gastrointestinale con metastasi ovariche bilaterali. Il caso in discussione ha risposto bene alle opzioni terapeutiche non invasive prima di procedere alla gestione chirurgica definitiva.
Target:
(68)Ga-DOTA-NOC/carcinoide gastrointestinale.
Sostanze: