Abstract
The melatonin hypothesis states that excess exposure to environmental light may contribute to breast cancer risks via impaired pineal secretion of melatonin. A corollary, not considered previously, is that a net annual increase in oncostatic melatonin would be expected in persons who experience a light deficit during extended winter darkness periods; thus, hormone-dependent cancers should occur less frequently in people who reside north, rather than south, of the Arctic circle. Consistent with our prediction, epidemiological data indicate uniformly low risks for hormone-dependent cancers in the Arctic. The available literature on genetic, reproductive, nutritional, life-style, and environmental risk factors provides no obvious clues to the observed cancer patterns. Moreover, diurnal and 24-hour melatonin concentrations in humans living in Arctic regions were reported as high in November-January, when light intensity is low. Since these observations are consistent with our corollary and the associated prediction, we suggest that research on a melatonin-inhibited carcinogenesis in the low-risk populations of the Arctic should be pursued.