Effects of the pineal hormone melatonin on the anchorage-independent growth of human breast cancer cells (MCF-7) in a clonogenic culture system

Riferimento: 
Cancer Lett. 1990 Apr 20;50(2):115-9.
Autori: 
Cos S, Blask DE.
Fonte: 
Cancer Lett. 1990 Apr 20;50(2):115-9.
Anno: 
1990
Azione: 
Cellular attachment may modify the sensitivity of MCF-7 cells towards melatonin.
Target: 
Anchorage-dependent

Abstract
Only physiological levels of melatonin exert an antiproliferative effect on MCF-7 breast cancer cells grown in an anchorage-dependent culture system. We investigated melatonin's effect on the anchorage-independent growth of MCF-7 cells as well as the dose-response characteristics of this indoleamine under clonogenic culture conditions. Melatonin's inhibitory effect, with respect to the number and size of colonies formed, exhibit a linear dose-response curve with pharmacological concentrations producing a maximal inhibition while subphysiological levels of melatonin induce minimal inhibition. These results indicate that cellular attachment may modify the sensitivity of MCF-7 cells towards melatonin.

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