Abstract
Only physiological levels of melatonin exert an antiproliferative effect on MCF-7 breast cancer cells grown in an anchorage-dependent culture system. We investigated melatonin's effect on the anchorage-independent growth of MCF-7 cells as well as the dose-response characteristics of this indoleamine under clonogenic culture conditions. Melatonin's inhibitory effect, with respect to the number and size of colonies formed, exhibit a linear dose-response curve with pharmacological concentrations producing a maximal inhibition while subphysiological levels of melatonin induce minimal inhibition. These results indicate that cellular attachment may modify the sensitivity of MCF-7 cells towards melatonin.
Effects of the pineal hormone melatonin on the anchorage-independent growth of human breast cancer cells (MCF-7) in a clonogenic culture system
Riferimento:
Cancer Lett. 1990 Apr 20;50(2):115-9.
Autori:
Cos S, Blask DE.
Fonte:
Cancer Lett. 1990 Apr 20;50(2):115-9.
Anno:
1990
Azione:
Cellular attachment may modify the sensitivity of MCF-7 cells towards melatonin.
Target:
Anchorage-dependent
Sostanze: