RXRgamma and PPARgamma ligands in combination to inhibit proliferation and invasiveness in colon cancer cells

Riferimento: 
Cancer Lett. 2010 Nov 1;297(1):65-74.
Autori: 
Papi A, Rocchi P, Ferreri AM, Orlandi M.
Fonte: 
Department of Experimental Evolutionary Biology, University of Bologna, Italy. alessio.papi2@unibo.it
Anno: 
2010
Azione: 
Il recettore nucleare X dei retinoidi (RXR) è candidato potenziale come bersaglio dei farmaci per la prevenzione e trattamento del cancro del colon.
Target: 
RXR/cancro del colon.

Nuclear retinoid X receptors (RXRs) and peroxisome proliferator-activated receptors (PPARs are potential candidates as drug target for cancer prevention and treatment. We investigated if the rexinoid 6-OH-11-O-hydroxyphenantrene (IIF) potentiates the antitumoral properties of PPARgamma ligands as ciglitazone and pioglitazone, on two colon cancer cell lines: HCA-7 and HCT-116. Drugs inhibited cell growth and induced apoptosis synergistically. The combination resulted in a decrease of cyclooxigenase-2, metalloproteinases-2 and -9 expression level and activity while PPARgamma, RXRgamma and tissue inhibitors of metalloproteinase-1 and -2 expression were increased. Finally, IIF potentiated PPAR transcriptional activity by enhancement of peroxisome proliferator response elements transactivation.

 

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