Tripartite motif 24 (Trim24/Tif1α) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor α (Rarα) inhibition

Riferimento: 
J Biol Chem. 2011 Sep 23;286(38):33369-79.
Autori: 
Tisserand J, Khetchoumian K, Thibault C, Dembélé D, Chambon P, Losson R.
Fonte: 
J Biol Chem. 2011 Sep 23;286(38):33369-79.
Anno: 
2011
Azione: 
Il recettore nucleare coregolatore (TRIM24) come nuovo regolatore negativo della via interferone (IFN)/proteine trasduttrici del segnale ed attivatrici della trascrizione (STAT), suggerendo che questa repressione attraverso l'inibizione del recettore α dell'acido retinoico (RARα) può prevenire il cancro al fegato.
Target: 
TRIM24-IFN-STAT- RARα/tumore fegato.

ABSTRACT
Recent genetic studies in mice have established that the nuclear receptor coregulator Trim24/Tif1α suppresses hepatocarcinogenesis by inhibiting retinoic acid receptor α (Rara)-dependent transcription and cell proliferation. However, Rara targets regulated by Trim24 remain unknown. We report that the loss of Trim24 resulted in interferon (IFN)/STAT pathway overactivation soon after birth (week 5). Despite a transient attenuation of this pathway by the induction of several IFN/STAT pathway repressors later in the disease, this phenomenon became more pronounced in tumors. Remarkably, Rara haplodeficiency, which suppresses tumorigenesis in Trim24(-/-) mice, prevented IFN/STAT overactivation. Moreover, together with Rara, Trim24 bound to the retinoic acid-responsive element of the Stat1 promoter and repressed its retinoic acid-induced transcription. Altogether, these results identify Trim24 as a novel negative regulator of the IFN/STAT pathway and suggest that this repression through Rara inhibition may prevent liver cancer.

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