ABSTRACT
Studies focused on elderly acute promyelocytic leukemia (APL) are relatively limited. To evaluate prognostic impact in elderly APL, we compared the long-term outcome of elderly APL patients (60-70 years) with younger patients (15-59 years) treated with all-trans retinoic acid combined with anthracycline and cytarabine in the Japan Adult Leukemia Study Group (JALSG) APL97 study. Of 283 evaluable patients, 46 (16.3%) were elderly who had more frequent lower platelet (P=0.04), lower albumin (P=0.006) and performance status 3 (P=0.02), higher induction death rate due to differentiation syndrome (P=0.03), and non-relapse mortality (NRM) during consolidation therapy (P=0.001). Overall survival was significantly inferior in elderly patients (P=0.005), but disease-free survival and cumulative incidence of relapse were not. Better therapeutic approaches should be considered to reduce NRM during induction and consolidation therapy in elderly APL.
Long-term outcome and prognostic factors of elderly patients with acute promyelocytic leukemia
Riferimento:
Cancer Sci. 2012 Nov;103(11):1974-8.
Autori:
Ono T, Takeshita A, Kishimoto Y, Kiyoi H, Okada M, Yamauchi T, Tsuzuki M, Horikawa K, Matsuda M, Shinagawa K, Monma F, Ohtake S, Nakaseko C, Takahashi M, Kimura Y, Iwanaga M, Asou N, Naoe T; Japan Adult Leukemia Study Group.
Fonte:
Cancer Sci. 2012 Nov;103(11):1974-8.
Anno:
2012
Azione:
Migliori approcci terapeutici dovrebbero essere considerati, per ridurre la mortalità non-recidiva (NRM) durante induzione e terapia di consolidamento, in pazienti anziani di leucemia.
Target:
ATRA-Antracicline-Citarabina/leucemia promielocitica acuta.
Sostanze: