Melatonina

Combined effects of melatonin and all-trans retinoic acid and somatostatin on breast cancer cell proliferation and death: molecular basis for the anticancer effect of these molecules

Eur J Pharmacol. 2012 Apr 15;681(1-3):34-43.
Margheri M, Pacini N, Tani A, Nosi D, Squecco R, Dama A, Masala E, Francini F, Zecchi-Orlandini S, Formigli L.
Administration of melatonin with all-trans retinoic acid and somatostatin may be of significant therapeutic benefit in breast cancer.
Melatonin effects potentiated

Correlation of the risk of breast cancer and disruption of the circadian rhythm (Review)

Oncol Rep. 2012 Aug;28(2):418-28.
Leonardi GC, Rapisarda V, Marconi A, Scalisi A, Catalano F, Proietti L, Travali S, Libra M, Fenga C.
Circadian system alteration and melatonin reduction, for exposure to light-at-night during night shift work, is the most valid hypotheses on the relation of shift work and breast cancer.
Night shift work

Health effects of extremely low-frequency magnetic fields: reconsidering the melatonin hypothesis in the light of current data on magnetoreception

J Appl Toxicol. 2012 Dec;32(12):952-8.
Vanderstraeten J, Verschaeve L, Burda H, Bouland C, de Brouwer C.
Study on disruption of circadian rhythmicity in humans (children if possible) under long-term exposure to weak ELF MF.
Extremely low-frequency (ELF) magnetic fields (MF)

Genome-wide profiling in melatonin-exposed human breast cancer cell lines identifies differentially methylated genes involved in the anticancer effect of melatonin

J Pineal Res. 2012 Jun 27.
Lee SE, Kim SJ, Yoon HJ, Yu SY, Yang H, Jeong SI, Hwang SY, Park CS, Park YS.
DNA methylation patterns induced by melatonin (1nm) suggest a potential mechanism of the anticancer effect in melatonin-treated breast cancer cells.
DNA methylation

Circadian Gating of Epithelial-to-Mesenchymal Transition in Breast Cancer Cells Via Melatonin-Regulation of GSK3β

Mol Endocrinol. 2012 Nov;26(11):1808-20.
Mao L, Dauchy RT, Blask DE, Slakey LM, Xiang S, Yuan L, Dauchy EM, Shan B, Brainard GC, Hanifin JP, Frasch T, Duplessis TT, Hill SM.
Melatonin activates GSK3β by inhibiting epithelial-to-mesenchymal transition, a fundamental process underlying cancer metastasis.
Glycogen synthase kinase 3β (GSK3β)

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