Leucemie Linfomi Mielomi
Anno: 1989
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Riferimento:Arch Histol Cytol. 1989;52 Suppl:69-74.Azione della melatonina:Serotonin is one of the representative biogenic amines produced from tryptophan in the gastrointestinal tract as well as in the brain. The capacity to synthesize serotonin depends on the existence of tryptophan monooxygenase. The activity of tryptophan monooxygenase in paraneurons such as mastocytomas and enterochromaffin cells depends on available ferrous iron.Target:L-5HTP monooxygenase.
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Riferimento:Neurochem Int. 1989;14(3):265-73.Azione della melatonina:Oncostatic effect of melatonin in the serum, 5-hydro-xyindole-O-methyltransferase activity, detection of neuromelanin pigment in pineal bodies.Target:The pineal pigment showed inverse relation with the prevalence of malignancy.
Anno: 1992
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Riferimento:Med Oncol Tumor Pharmacother. 1992;9(2):87-92.Azione della melatonina:Accelerated leukemogenesis whereas the surgical pinealectomy and the functional pinealectomy delayed it.Target:Daily melatonin 4 mg/kg b.w.
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Riferimento:Med Oncol Tumor Pharmacother. 1992;9(2):87-92.Azione della melatonina:Involvement of melatonin-induced-immuno-opioids in the development of the lymphomas. Melatonin 4 mg/kg bw, chronically treated.Target:Melatonin was blocked by naltrexone.
Anno: 1993
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Riferimento:Int J Biochem. 1993 Mar;25(3):441-4.Azione della melatonina:Mlt (200 microM) affect selectively the processes of lymphoblastoid cell growth.Target:Inhibition of [3H]thymidine incorporation.
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Riferimento:Int J Biochem. 1993 Mar;25(3):441-4.Azione della melatonina:Affect selectively the processes of lymphoblastoid cell growth.Target:200 microM in vitro.
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Titolo: Vitiligo: where do we stand?Riferimento:Pigment Cell Res. 1993 Mar;6(2):61-72.Azione della melatonina:Abnormalities in a putative melatonin receptor on melanocytes.Target:Several different pathogenetic mechanisms.
Anno: 1994
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Titolo: Melatonin concentrations in pineal organ culture are suppressed by sera from tumor-bearing miceRiferimento:J Pineal Res. 1994 Aug;17(1):17-9.Azione della melatonina:Melatonin rhythmicity is suppressed in cancer patients.Target:Plasma borne tumor-associated factor (TAMF).
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Riferimento:J Natl Cancer Inst. 1994 Jun 15;86(12):921-5.Azione della melatonina:Exposure to extremely low-frequency electromagnetic fields reduces the pineal gland's nocturnal production of the hormone melatonin.Target:Electric or magnetic fields.
Anno: 1995
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Titolo: The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytesRiferimento:J Biol Chem. 1995 Mar 31;270(13):7037-40.Azione della melatonina:Melatonin is a natural ligand of RZR alpha and RZR beta, down-regulating the expression of 5-lipoxygenase about 5-fold in B-Lymphocytes.Target:Retinoid Z receptor (RZR alpha and beta).