Leucemie Linfomi Mielomi
Anno: 1999
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Riferimento:Immunology. 1999 Feb;96(2):291-7.Azione della melatonina:Dhea and Mlt simultaneously reduced hepatic lipid peroxidation and prevent vitamin E loss.Target:Prevent (Th1, Th2) cyto-kine dysregulation.
Anno: 2000
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Riferimento:Anticancer Res. 2000 May-Jun;20(3B):2103-5.Azione della melatonina:The concomitant administration of low-dose IL-2 plus Mlt may prolong the survival time in untreatable advanced hematologic malignancies.Target:Low doses of Interleukin-2 (IL-2).
Anno: 2001
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Riferimento:Cancer Biother Radiopharm. 2001 Apr;16(2):171-7.Azione della melatonina:The association of cyclophos., somato., bromo., retin. melat., ACTH is well tolerated and effective in treat. of low-grade NHL at advanced stage.Target:Low-grade NHL, stage III or IV.
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Riferimento:J Pineal Res. 2001 Oct;31(3):206-13.Azione della melatonina:In the concentration range 10-2000 pg/ml causes an inhibition of the growth of the human cell lines is not clearly dose-dependent and less than 25% when significant. 200-1000 pg/ml melatonin cause a significant sensitization to doxorubicin.Target:Might inhibit P-glycopro tein-mediated doxorubicin efflux from the cells.
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Titolo: Echinacea purpurea and melatonin augment natural-killer cells in leukemic mice and prolong life spanRiferimento:J Altern Complement Med. 2001 Jun;7(3):241-51.Azione della melatonina:Leukemic mice received the NK-enhancing melatonin, administered daily for 50 days. At 3 months post tumor onset, all the major hemopoietic, were recorded at normal numbers.Target:Natural-killer (NK) cells.
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Riferimento:Environ Res. 2001 Feb;85(2):115-21.Azione della melatonina:Long-term and continuous exposure to simulate powerline magnetic fields did not result in a decreased nocturnal melatonin secretion in mice.Target:Average of 2.75 microT magnetic fields.
Anno: 2002
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Riferimento:Med Hypotheses. 2002 Jul;59(1):39-51.Azione della melatonina:A link with breast and other cancers has been postuated via modified melatonin activity.Target:Magnetic field exposures above 0.1 mT.
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Titolo: Melatonin deficiencies in womenRiferimento:Maturitas. 2002 Apr 15;41 Suppl 1:S85-104.Azione della melatonina:Constant application of benzodiazepine reduced the production of natural melatonin in rats.Target:Melatonin acts via the gamma-aminobutyric acid-benzodiazepine receptor.
Anno: 2004
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Riferimento:Biochem Pharmacol. 2004 Nov 1;68(9):1869-78.Azione della melatonina:6-Hydroxymelatonin induced site-specific DNA damage in the presence of Cu(II). Damaged G and C of the 5'-ACG-3' sequence complementary to codon 273 of the p53 gene.Target:Oxidative DNA damage by its metabolite.
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Riferimento:J Cell Biochem. 2004 Sep 1;93(1):83-92.Azione della melatonina:Electromagnetic field (EMF) and extremely low frequency (ELF) exposure is able to perform such activation by means of increasing levels of free radicals, causing an inhibition of the effects of the melatonin.Target:DNA damage.