Leucemie Linfomi Mielomi
Anno: 1999
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Riferimento:Immunology. 1999 Feb;96(2):291-7.Azione della melatonina:Dhea and Mlt simultaneously reduced hepatic lipid peroxidation and prevent vitamin E loss.Target:Prevent (Th1, Th2) cyto-kine dysregulation.
Anno: 2000
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Riferimento:Anticancer Res. 2000 May-Jun;20(3B):2103-5.Azione della melatonina:The concomitant administration of low-dose IL-2 plus Mlt may prolong the survival time in untreatable advanced hematologic malignancies.Target:Low doses of Interleukin-2 (IL-2).
Anno: 2001
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Riferimento:Cancer Biother Radiopharm. 2001 Apr;16(2):171-7.Azione della melatonina:The association of cyclophos., somato., bromo., retin. melat., ACTH is well tolerated and effective in treat. of low-grade NHL at advanced stage.Target:Low-grade NHL, stage III or IV.
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Riferimento:J Pineal Res. 2001 Oct;31(3):206-13.Azione della melatonina:In the concentration range 10-2000 pg/ml causes an inhibition of the growth of the human cell lines is not clearly dose-dependent and less than 25% when significant. 200-1000 pg/ml melatonin cause a significant sensitization to doxorubicin.Target:Might inhibit P-glycopro tein-mediated doxorubicin efflux from the cells.
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Titolo: Echinacea purpurea and melatonin augment natural-killer cells in leukemic mice and prolong life spanRiferimento:J Altern Complement Med. 2001 Jun;7(3):241-51.Azione della melatonina:Leukemic mice received the NK-enhancing melatonin, administered daily for 50 days. At 3 months post tumor onset, all the major hemopoietic, were recorded at normal numbers.Target:Natural-killer (NK) cells.
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Riferimento:Environ Res. 2001 Feb;85(2):115-21.Azione della melatonina:Long-term and continuous exposure to simulate powerline magnetic fields did not result in a decreased nocturnal melatonin secretion in mice.Target:Average of 2.75 microT magnetic fields.
Anno: 2002
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Riferimento:Med Hypotheses. 2002 Jul;59(1):39-51.Azione della melatonina:A link with breast and other cancers has been postuated via modified melatonin activity.Target:Magnetic field exposures above 0.1 mT.
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Titolo: Melatonin deficiencies in womenRiferimento:Maturitas. 2002 Apr 15;41 Suppl 1:S85-104.Azione della melatonina:Constant application of benzodiazepine reduced the production of natural melatonin in rats.Target:Melatonin acts via the gamma-aminobutyric acid-benzodiazepine receptor.
Anno: 2004
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Titolo: Melatonin and viral infectionsRiferimento:J Pineal Res. 2004 Mar;36(2):73-9.Azione della melatonina:This indole inhibits nitric oxide synthetase activity and it is a potent scavenger of nitric oxide.Target:Interleukin-1beta, tumor necrosis factor-alpha.
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Riferimento:Biochem Pharmacol. 2004 Nov 1;68(9):1869-78.Azione della melatonina:6-Hydroxymelatonin induced site-specific DNA damage in the presence of Cu(II). Damaged G and C of the 5'-ACG-3' sequence complementary to codon 273 of the p53 gene.Target:Oxidative DNA damage by its metabolite.