Leucemie Linfomi Mielomi
Anno: 2004
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Titolo: Melatonin and viral infectionsRiferimento:J Pineal Res. 2004 Mar;36(2):73-9.Azione della melatonina:This indole inhibits nitric oxide synthetase activity and it is a potent scavenger of nitric oxide.Target:Interleukin-1beta, tumor necrosis factor-alpha.
Anno: 2005
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Riferimento:Bioelectromagnetics. 2005;Suppl 7:S86-97.Azione della melatonina:Magnetic fields suppress the nocturnal production of melatonin, for childhood leukemia exposures above 0.3/0.4 microT.Target:Highly protective of oxidative damage to human haemopoietic system.
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Riferimento:Toxicol Ind Health. 2005 Nov;21(10):273-82.Azione della melatonina:Disrupted sleep pattern, hyposecretion of melatonin.Target:Kaposi's sarcoma, non-Hodgkin's lymphoma.
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Titolo: Could visible light contribute to the development of leukaemia and other cancers in children?Riferimento:Med Hypotheses. 2005;64(4):864-71.Azione della melatonina:Visible light suppresses melatonin biosynthesis which may play a role in a series of anticancer defences.Target:Endocrine systems and photoreceptors in the eye.
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Riferimento:J Pineal Res. 2005 Nov;39(4):425-31.Azione della melatonina:Apoptotic effect of melatonin is associated with cell-cycle arrest, downregulation of Bcl-2, mitochondrial membrane depolarization, cytochrome c release and activation of caspase-3.Target:Bcl-2, Cytochrome c, Caspase-3.
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Riferimento:Vopr Onkol. 2005;51(1):93-8.Azione della melatonina:Melatonin, in water 20mg/ml during the night hours, failed to influence tumor incidence.Target:SAMP-1 and SAMR-1 mice.
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Riferimento:Neuro Endocrinol Lett. 2005 Apr;26(2):136-42.Azione della melatonina:Exposure to extremely low frequency electromagnetic fields has been suggested to suppress melatonin secretion.Target:ELF-EMF
Anno: 2006
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Riferimento:Int J Exp Pathol. 2006 Apr;87(2):81-7.Azione della melatonina:Powerful antiapoptotic signal promoting the survival of normal granulocytes and B lymphocytes.Target:T-helper 1 (Th1) cytoki- nes, natural killer (NK) cells.
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Riferimento:Hum Genomics. 2006 Mar;2(5):329-35.Azione della melatonina:NQO2 gene has a melatonin-binding site, which may explain its anti-oxidant role.Target:One - and two-electron reductions of quinones.
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Riferimento:Fundam Clin Pharmacol. 2006 Feb;20(1):73-9.Azione della melatonina:Induces the production of ROS that may be associated with cytotoxicity depending on its concentration.Target:These pro-oxidant actions may assist in limiting leukemic cell growth.