Leucemie Linfomi Mielomi
Anno: 2006
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Riferimento:J Pineal Res. 2006 Mar;40(2):158-67.Azione della melatonina:U937 promonocytic leukemia cells was treated with 1mM melatonin before and after UV-B exposure.Target:Pretreatment reduced the number of apoptotic cells while post treatment delay.
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Riferimento:Am J Ther. 2006 Nov-Dec;13(6):556-7.Azione della melatonina:After 2 months, patient had a partial response, and after 5 months he achieved a complete response.Target:High-grade NHL after auto-SCT.
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Riferimento:Indian J Med Sci. 2006 Dec;60(12):523-35.Azione della melatonina:Exposure to light at night (LAN) and anthropogenic electric and magnetic fields (EMFs) is related to the increased incidence of breast cancer and childhood leukaemia via melatonin disruption.Target:Immunomodulator and oncostatic agent.
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Riferimento:Int J Exp Pathol. 2006 Apr;87(2):81-7.Azione della melatonina:Powerful antiapoptotic signal promoting the survival of normal granulocytes and B lymphocytes.Target:T-helper 1 (Th1) cytoki- nes, natural killer (NK) cells.
Anno: 2007
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Riferimento:Am J Ther. 2007 Jan-Feb;14(1):113-5.Azione della melatonina:After 2 months the patient had a partial response, and after 5 months he achieved a complete response.Target:Treatment had very good tolerance.
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Titolo: Inhibition of proliferation and induction of apoptosis by melatonin in human myeloid HL-60 cellsRiferimento:J Pineal Res. 2007 Mar;42(2):131-8.Azione della melatonina:Inhibiting progression from G(1) to S phase of the cell cycle and increasing apoptotic cell death.Target:Elevated cytochrome c release from mitochondria augmented caspase-3 and caspase-9 activities, regulation of Bax/Bcl-2 expression.
Anno: 2008
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Riferimento:J Pineal Res. 2008 Apr;44(3):307-15.Azione della melatonina:Melatonin administration (2 mg/kg BW/day) enhances survival under LD conditions, the results are self-defeating when they coexist with circadian disruption as under LL conditions.Target:Light-dark (LD) Continuous light (LL).
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Riferimento:Hybridoma (Larchmt). 2008 Jun;27(3):205-9.Azione della melatonina:Anti-melatonin monoclonal antibodies (Mab) may be useful for immunoassay of melatonin.Target:Mab-BSA( bovine serum albumin) intraperitonally.
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Riferimento:J Pineal Res. 2008 Apr;44(3):307-15.Azione della melatonina:Importance of taking into account endogenous rhythmicity and limiting melatonin administration to the subjective night (2 mg/kg BW/day) in order to restrict melanoma progression.Target:Circadian rhythmicity.
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Riferimento:J Pineal Res. 2008 Nov;45(4):341-50.Azione della melatonina:Highly protective of oxidative damage to the human hemopoietic system.Target:Disruption of nocturnal melatonin synthesis andrelated circadian rhythms by electric fields.