Leucemie Linfomi Mielomi
Anno: 2006
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Riferimento:Int J Exp Pathol. 2006 Apr;87(2):81-7.Azione della melatonina:Powerful antiapoptotic signal promoting the survival of normal granulocytes and B lymphocytes.Target:T-helper 1 (Th1) cytoki- nes, natural killer (NK) cells.
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Riferimento:Hum Genomics. 2006 Mar;2(5):329-35.Azione della melatonina:NQO2 gene has a melatonin-binding site, which may explain its anti-oxidant role.Target:One - and two-electron reductions of quinones.
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Riferimento:Fundam Clin Pharmacol. 2006 Feb;20(1):73-9.Azione della melatonina:Induces the production of ROS that may be associated with cytotoxicity depending on its concentration.Target:These pro-oxidant actions may assist in limiting leukemic cell growth.
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Riferimento:J Pineal Res. 2006 May;40(4):350-4.Azione della melatonina:The roles of the indole nucleus and the side chain in the determination of the antigenic properties of the molecule are discussed.Target:Mab-BSA multifocal intradermal jniections.
Anno: 2007
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Titolo: Inhibition of proliferation and induction of apoptosis by melatonin in human myeloid HL-60 cellsRiferimento:J Pineal Res. 2007 Mar;42(2):131-8.Azione della melatonina:Inhibiting progression from G(1) to S phase of the cell cycle and increasing apoptotic cell death.Target:Elevated cytochrome c release from mitochondria augmented caspase-3 and caspase-9 activities, regulation of Bax/Bcl-2 expression.
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Riferimento:Am J Ther. 2007 Jan-Feb;14(1):113-5.Azione della melatonina:After 2 months the patient had a partial response, and after 5 months he achieved a complete response.Target:Treatment had very good tolerance.
Anno: 2008
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Riferimento:J Pineal Res. 2008 Apr;44(3):307-15.Azione della melatonina:Importance of taking into account endogenous rhythmicity and limiting melatonin administration to the subjective night (2 mg/kg BW/day) in order to restrict melanoma progression.Target:Circadian rhythmicity.
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Riferimento:J Pineal Res. 2008 Nov;45(4):341-50.Azione della melatonina:Highly protective of oxidative damage to the human hemopoietic system.Target:Disruption of nocturnal melatonin synthesis andrelated circadian rhythms by electric fields.
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Riferimento:Endokrynol Pol. 2008 May-Jun;59(3):200-6.Azione della melatonina:Not influenced the activity of GSH-Px, either in normal or in pinealectomised rats after ADR. A deficiency of endogenous melatonin production may inhibit GSH-Px activity.Target:ADR; GSH-Px.
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Riferimento:J Pineal Res. 2008 Apr;44(3):307-15.Azione della melatonina:Melatonin administration (2 mg/kg BW/day) enhances survival under LD conditions, the results are self-defeating when they coexist with circadian disruption as under LL conditions.Target:Light-dark (LD) Continuous light (LL).