Melatonina
Anno: 2011
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Riferimento:J Pineal Res. 2011 Apr;50(3):345-55.Azione della melatonina:Induction of cell death in several human malignant haematological cell lines through the activation of the extrinsic pathway of apoptosis.Target:Death receptors Fas, DR4 and DR5 and their ligands Fas L and TRAIL.
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Riferimento:J Pineal Res. 2011 May;50(4):367-73.Azione della melatonina:Significantly augmented the cytotoxicity of puro-mycin in HL-60 cells.Target:AMPK.phosphorylation of 5'-
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Titolo: Melatonin and associated signaling pathways that control normal breast epithelium and breast cancerRiferimento:J Mammary Gland Biol Neoplasia. 2011 Sep;16(3):235-45.Azione della melatonina:Light-at-night (LAN) induced circadian disruption of the nocturnal melatonin signal activates human breast cancer growth.Target:MT(1)melatonin receptors Estrogen receptor-positive (Erα+), G(αi2) signaling.
Anno: 2012
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Riferimento:J Pineal Res. 2012 Jun 27.Azione della melatonina:DNA methylation patterns induced by melatonin (1nm) suggest a potential mechanism of the anticancer effect in melatonin-treated breast cancer cells.Target:DNA methylation
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Riferimento:Am J Epidemiol. 2012 Nov 1;176(9):751-9.Azione della melatonina:Night work may increase cancer risk at several sites among men, possibly via suppression of melatonin release.Target:Night work.
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Riferimento:J Appl Toxicol. 2012 Dec;32(12):952-8.Azione della melatonina:Study on disruption of circadian rhythmicity in humans (children if possible) under long-term exposure to weak ELF MF.Target:Extremely low-frequency (ELF) magnetic fields (MF)
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Riferimento:J Pineal Res. 2012 Apr;52(3):322-31.Azione della melatonina:Melatonin sensitizes human hepatoma cells to ER tress-induced apoptosis by down-regulating COX-2 xpression, incresing the levels of CHOP and decreaing the Bcl-2/Bax ratio.Target:Endoplasmin reticulum, Cyclooxygenase-2, Pro-apoptotic transcription factor.
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Riferimento:Recent Pat Anticancer Drug Discov. 2012 Sep;7(3):337-44.Azione della melatonina:Systemic effects of darkness and excessive melatonin synthesis enables cancer protection treatment for people living in light-deficient environment.Target:Racial/ethnic disparities
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Riferimento:Oncol Rep. 2012 Aug;28(2):418-28.Azione della melatonina:Circadian system alteration and melatonin reduction, for exposure to light-at-night during night shift work, is the most valid hypotheses on the relation of shift work and breast cancer.Target:Night shift work
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Titolo: A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkersRiferimento:Cancer Causes Control. 2012 Apr;23(4):609-16.Azione della melatonina:Effects of melatonin supplementation (3 mg oral melatonin, daily for 4 months) in postmenopausal breast cancer survivors.Target:Estradiol-lowering effects of melatonin.