Melatonina
Anno: 2012
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Riferimento:BMJ Open. 2012 Jan 21;2(1).Azione della melatonina:Inverse relationship between aMTs-6(6-sulfatoxymelatonin) and oestradiol was suggested in the winter.Target:Long-term shift work as a probable carcinogen.
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Riferimento:Breast Cancer (Auckl). 2012;6:137-50.Azione della melatonina:Melatonin administration following serum shock differentially suppressed or induced clock gene (Bmal1 and Per2) and CCG expression in MCF10A and MCF-7 cells.Target:Clock and clock-controlled genes (CCGs)
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Riferimento:Mol Endocrinol. 2012 Nov;26(11):1808-20.Azione della melatonina:Melatonin activates GSK3β by inhibiting epithelial-to-mesenchymal transition, a fundamental process underlying cancer metastasis.Target:Glycogen synthase kinase 3β (GSK3β)
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2012 Apr;21(4):609-18.Azione della melatonina:Night shift work may disrupt the normal nocturnal rise in melatonin, resulting in increased breast cancer risk.Target:Reduced 6-sulfatoxymelatonin levels during night work and daytime sleep.
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Riferimento:J Pineal Res. 2012 Aug 16.Azione della melatonina:Melatonin(1mm) play a role in the paracrine interactions between malignant epithelial cells and proximal endothelial cells through a downregulatory action on VEGF expression in human breast cancer cells, as well as decreasing tumoral angiogenesis.Target:Vascular endothelial growth factor (VEGF)
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Riferimento:Cell Mol Life Sci. 2012 Sep 25.Azione della melatonina:Melatonin acts at different mechanisms of action, nvolving apoptosis activation, inhibition of proliferation, and cell differentiation.Target:Melatonin acts at different physiological levels.
Anno: 2013
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Riferimento:Breast Cancer Res Treat. 2013 Feb;137(3):677-87.Azione della melatonina:Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.Target:TNBC
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Riferimento:BMC Cell Biol. 2013 Jan 7;14:1.Azione della melatonina:Melatonin enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.Target:DNA repair capacity