Melatonina
Anno: 2012
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Riferimento:Dig Dis Sci. 2012 Oct 10.Azione della melatonina:Supplementation by exogenous melatonin (20 and 40 mg/kg body weight) significantly reduces MTX-induced small intestinal damage.Target:Methotrexate (MTX).
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Riferimento:Oncol Rep. 2012 Aug;28(2):418-28.Azione della melatonina:Circadian system alteration and melatonin reduction, for exposure to light-at-night during night shift work, is the most valid hypotheses on the relation of shift work and breast cancer.Target:Night shift work
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Riferimento:Breast Cancer Res Treat. 2012 Apr;132(2):693-9.Azione della melatonina:Genetic variation in the MTNR1a and 1b genes may contribute to breast cancer, no breast cancer associations were found for variants in the AANAT gene.Target:Mlt receptors 1a and 1b (MTNR1a and MTNR1b), arylalkylamine N-acetyl-transferase (AANAT).
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Riferimento:Recent Pat Anticancer Drug Discov. 2012 Sep;7(3):337-44.Azione della melatonina:Systemic effects of darkness and excessive melatonin synthesis enables cancer protection treatment for people living in light-deficient environment.Target:Racial/ethnic disparities
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Riferimento:J Pineal Res. 2012 Apr;52(3):322-31.Azione della melatonina:Melatonin sensitizes human hepatoma cells to ER tress-induced apoptosis by down-regulating COX-2 xpression, incresing the levels of CHOP and decreaing the Bcl-2/Bax ratio.Target:Endoplasmin reticulum, Cyclooxygenase-2, Pro-apoptotic transcription factor.
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Titolo: Melatonin interferes in the desmoplastic reaction in breast cancer by regulating cytokine productionRiferimento:J Pineal Res. 2012 Apr;52(3):282-90.Azione della melatonina:One millimolar melatonin induced a reduction in TNF-α, IL-6, and IL-11 mRNA expression in MCF-7 and 3T3-L1 cells.Target:Aromatase enzyme,tumor necrosis factor (TNF)-α, interleukin (IL)-11 and interleukin (IL)-6.
Anno: 2013
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Riferimento:Breast Cancer Res Treat. 2013 Feb;137(3):677-87.Azione della melatonina:Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.Target:TNBC
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Riferimento:BMC Cell Biol. 2013 Jan 7;14:1.Azione della melatonina:Melatonin enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.Target:DNA repair capacity