Melatonina

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Azione della melatonina

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Anno: 2012

Titolo: A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis

Riferimento:
Eur J Cancer Prev. 2012 Mar;21(2):163-70.

Azione della melatonina:
Resveratrol in combination with melatonin has some protective effects on N-methyl-N-nitrosourea (NMU)-induced rodent breast cancer.

Target:
Chemoprevention with resveratrol and mlt.
Titolo: Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells

Riferimento:
J Pineal Res. 2012 Aug 16.

Azione della melatonina:
Melatonin(1mm) play a role in the paracrine interactions between malignant epithelial cells and proximal endothelial cells through a downregulatory action on VEGF expression in human breast cancer cells, as well as decreasing tumoral angiogenesis.

Target:
Vascular endothelial growth factor (VEGF)
Titolo: Molecular mechanisms of melatonin's inhibitory actions on breast cancers

Riferimento:
Cell Mol Life Sci. 2012 Sep 25.

Azione della melatonina:
Melatonin acts at different mechanisms of action, nvolving apoptosis activation, inhibition of proliferation, and cell differentiation.

Target:
Melatonin acts at different physiological levels.
Titolo: Oscillation of clock and clock controlled genes induced by serum shock in human breast epithelial and breast cancer cells: regulation by melatonin

Riferimento:
Breast Cancer (Auckl). 2012;6:137-50.

Azione della melatonina:
Melatonin administration following serum shock differentially suppressed or induced clock gene (Bmal1 and Per2) and CCG expression in MCF10A and MCF-7 cells.

Target:
Clock and clock-controlled genes (CCGs)
Titolo: Melatonin promotes differentiation of 3T3-L1 fibroblasts

Riferimento:
J Pineal Res. 2012 Jan;52(1):12-20.

Azione della melatonina:
Mlt (1mM) could stimulate the differentiation of preadipocytes (3T3-L1) into adipocytes.

Target:
3T3-L1 adipocytes.
Titolo: Circadian Gating of Epithelial-to-Mesenchymal Transition in Breast Cancer Cells Via Melatonin-Regulation of GSK3β

Riferimento:
Mol Endocrinol. 2012 Nov;26(11):1808-20.

Azione della melatonina:
Melatonin activates GSK3β by inhibiting epithelial-to-mesenchymal transition, a fundamental process underlying cancer metastasis.

Target:
Glycogen synthase kinase 3β (GSK3β)

Anno: 2013

Titolo: Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathw

Riferimento:
BMC Cell Biol. 2013 Jan 7;14:1.

Azione della melatonina:
Melatonin enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.

Target:
DNA repair capacity
Titolo: Expression of melatonin receptors in triple negative breast cancer (TNBC) in African American and Caucasian women: relation to survival

Riferimento:
Breast Cancer Res Treat. 2013 Feb;137(3):677-87.

Azione della melatonina:
Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.

Target:
TNBC

A.I.A.N. - Modena

Melatonina

Anno: 2012

Anno: 2013

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