Melatonina
Anno: 2012
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Riferimento:Int J Cancer. 2012 May 30.Azione della melatonina:Sleep duration is not significantly associated with breast cancer risk reduction.Target:6-sulfatoxymelatonin (aMT6s)
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Riferimento:Scand J Work Environ Health. 2012 Jul 1;38(4):380-90.Azione della melatonina:Elevations in risk of breast cancer after about 20 years working night shift. Accelerated tumor growth by suppression of melatonin secretion.Target:Shift work carcinogenic to humans (group 2A).
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Riferimento:Eur J Pharmacol. 2012 Apr 15;681(1-3):34-43.Azione della melatonina:Administration of melatonin with all-trans retinoic acid and somatostatin may be of significant therapeutic benefit in breast cancer.Target:Melatonin effects potentiated
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Riferimento:J Pineal Res. 2012 Aug;53(1):77-90.Azione della melatonina:Inhibits cell proliferation and induces apoptosis in MDA-MB-361 breast cancer cells in vitro by simultaneously suppressing the COX-2/PGE2, p300/NF-κB and PI3K/Akt/signaling and activating the Apaf-1/ caspase-dependent apoptotic pathway.Target:Mlt 10(-3)M
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Riferimento:Mol Carcinog. 2012 Aug;51(8):608-18.Azione della melatonina:Melatonin inhibits growth and invasive capacity of colon cancer cells in vitro through its membrane (MT1 and MT2) and/or nuclear receptors (RORα).Target:MT1- MT2 - RORα
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Riferimento:Expert Opin Investig Drugs. 2012 Jun;21(6):819-31.Azione della melatonina:Melatonin could be an excellent adjuvant with the drugs currently used for breast cancer prevention.Target:Selective estrogen receptor/enzyme modulators
Anno: 2013
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Riferimento:BMC Cell Biol. 2013 Jan 7;14:1.Azione della melatonina:Melatonin enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.Target:DNA repair capacity
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Riferimento:Breast Cancer Res Treat. 2013 Feb;137(3):677-87.Azione della melatonina:Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.Target:TNBC