Melatonina
Anno: 2012
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Riferimento:Mol Endocrinol. 2012 Nov;26(11):1808-20.Azione della melatonina:Melatonin activates GSK3β by inhibiting epithelial-to-mesenchymal transition, a fundamental process underlying cancer metastasis.Target:Glycogen synthase kinase 3β (GSK3β)
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2012 Apr;21(4):609-18.Azione della melatonina:Night shift work may disrupt the normal nocturnal rise in melatonin, resulting in increased breast cancer risk.Target:Reduced 6-sulfatoxymelatonin levels during night work and daytime sleep.
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Riferimento:J Pineal Res. 2012 Aug 16.Azione della melatonina:Melatonin(1mm) play a role in the paracrine interactions between malignant epithelial cells and proximal endothelial cells through a downregulatory action on VEGF expression in human breast cancer cells, as well as decreasing tumoral angiogenesis.Target:Vascular endothelial growth factor (VEGF)
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Riferimento:Cell Mol Life Sci. 2012 Sep 25.Azione della melatonina:Melatonin acts at different mechanisms of action, nvolving apoptosis activation, inhibition of proliferation, and cell differentiation.Target:Melatonin acts at different physiological levels.
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Riferimento:J Pineal Res. 2012 Aug;53(1):77-90.Azione della melatonina:Inhibits cell proliferation and induces apoptosis in MDA-MB-361 breast cancer cells in vitro by simultaneously suppressing the COX-2/PGE2, p300/NF-κB and PI3K/Akt/signaling and activating the Apaf-1/ caspase-dependent apoptotic pathway.Target:Mlt 10(-3)M
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Riferimento:Am J Epidemiol. 2012 Nov 1;176(9):760-3.Azione della melatonina:Direct oncostatic properties of melatonin in shift-work-cancer association.Target:Night-shift work
Anno: 2013
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Riferimento:Breast Cancer Res Treat. 2013 Feb;137(3):677-87.Azione della melatonina:Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.Target:TNBC
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Riferimento:BMC Cell Biol. 2013 Jan 7;14:1.Azione della melatonina:Melatonin enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.Target:DNA repair capacity