Anno: 1993

• Titolo: [Melatonin, a clinically important hormone?]
  Riferimento:

  Dtsch Med Wochenschr. 1983 Mar 25;108(12):470-4. Review.
  Azione della melatonina:

  No abstract available.
  Target:

  No abstract available.
• Titolo: Biologically based epidemiological studies of electric power and cancer
  Riferimento:

  Environ Health Perspect. 1993 Dec;101 Suppl 4:93-100.
  Azione della melatonina:

  Effects on: DNA transcription and translation, calcium balance in cells, pineal production of mlt.
  Target:

  Electromagnetic fields (EMF)
• Titolo: Melatonin modulation of estrogen-receptor expression in mcf-7 human breast-cancer cells
  Riferimento:

  Int J Oncol. 1993 Oct;3(4):687-94.
  Azione della melatonina:

  Antimitotic actions of melatonin(10(-8)-10(-11) M) may be mediated through the suppression of the estrogen-response pathway of MCF-7 cells.
  Target:

  Estrogen receptor (ER)
• Titolo: Cancer immunotherapy with low-dose interleukin-2 subcutaneous administration: potential efficacy in most solid tumor histotypes by a concomitant treatment with the pineal hormone melatonin
  Riferimento:

  J Biol Regul Homeost Agents. 1993 Oct-Dec;7(4):121-5.
  Azione della melatonina:

  In advanced solid neoplasms, have been associated IL-2 with melatonin (MLT)(40 mg/day orally). Objective tumor regression were achieved in 17/82 (21%) patients.
  Target:

  MLT / IL-2
• Titolo: ELF magnetic fields, breast cancer, and melatonin: 60 Hz fields block melatonin's oncostatic action on ER+ breast cancer cell proliferation
  Riferimento:

  J Pineal Res. 1993 Mar;14(2):89-97.
  Azione della melatonina:

  ELF frequency magnetic fields can act cancer cell proliferation by blocking melatonin(10(-9) M) oncostatic action.
  Target:

  60 Hz magnetic field
• Titolo: Breast cancer and electric power
  Riferimento:

  Biomed Pharmacother. 1993;47(10):435-8. Review.
  Azione della melatonina:

  These can reduce nocturnal melatonin production.
  Target:

  Light-at-night/electromagnetic fields
• Titolo: Selective effect of melatonin on the proliferation of lymphoid cells
  Riferimento:

  Int J Biochem. 1993 Mar;25(3):441-4.
  Azione della melatonina:

  Mlt (200 microM) affect selectively the processes of lymphoblastoid cell growth.
  Target:

  Inhibition of [3H]thymidine incorporation.
• Titolo: Electromagnetic fields and male breast cancer
  Riferimento:

  Biomed Pharmacother. 1993;47(10):425-7. Review
  Azione della melatonina:

  Pineal function is suppressed by light-at-night(LAN) 60-Hz electric fields suppress the nocturnal rise in pineal melatonin production.
  Target:

  Electromagnetic fields Light-at-night
• Titolo: Selective effect of melatonin on the proliferation of lymphoid cells
  Riferimento:

  Int J Biochem. 1993 Mar;25(3):441-4.
  Azione della melatonina:

  Affect selectively the processes of lymphoblastoid cell growth.
  Target:

  200 microM in vitro.
• Titolo: Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancers of the digestive tract
  Riferimento:

  Br J Cancer.1993 Jun;67(6):1404-7.
  Azione della melatonina:

  The immunotherapy with low-dose IL-2 plus MLT (50mg/day orally) is a new well tolerated and effective therapy of advanced tumours of digestive tract.
  Target:

  Interleukin 2 (IL-2) plus MLT.