Melatonina

Target

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Azione della melatonina

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Anno: 1993

Titolo: Neuroimmunotherapy of advanced solid neoplasms with single evening subcutaneous injection of low-dose interleukin-2 and melatonin: preliminary results

Riferimento:
Eur J Cancer. 1993;29A(2):185-9.

Azione della melatonina:
Neuroimmunotherapy with low-dose IL-2 and MLT (50mg/day orally) is a biologically active and well tolerated strategy, capable of determining an apparent control of tumour growth in patients with advanced solid neoplasms.

Target:
Interleukin 2 (IL-2) plus .MLT
Titolo: [Melatonin, a clinically important hormone?]

Riferimento:
Dtsch Med Wochenschr. 1983 Mar 25;108(12):470-4. Review.

Azione della melatonina:
No abstract available.

Target:
No abstract available.

Anno: 1994

Titolo: Breast cancer mortality among female electrical workers in the United States

Riferimento:
J Natl Cancer Inst. 1994 Jun 15;86(12):921-5.

Azione della melatonina:
Exposure to extremely low-frequency electromagnetic fields reduces the pineal gland's nocturnal production of the hormone melatonin.

Target:
Electric or magnetic fields.
Titolo: A randomised study with subcutaneous low-dose interleukin 2 alone vs interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma

Riferimento:
Br J Cancer. 1994 Jan;69(1):196-9.

Azione della melatonina:
The concomitant administration of MLT (40 mg day orally) may increase the efficacy of low-dose IL-2 subcutaneous therapy.Tumour objective regression rate was 11/41 vs 1/39, P < 0.001.

Target:
Interleukin 2 (IL-2) plus MLT.
Titolo: Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells.

Riferimento:
Mol Endocrinol. 1994 Dec;8(12):1681-90.

Azione della melatonina:
Antiproliferative actions of Mlt are mediated through the suppression of the transcription of ER gene.

Target:
Estrogen receptor (ER) mRNA
Titolo: Serial transplants of 7,12-dimethylbenz[a]anthracene-induced mammary tumors in Fischer rats as model system for human breast cancer. 3. Quantitative ultrastructural studies of the pinealocytes and plasma melatonin concentrations in rats bearing an advance

Riferimento:
Biol Signals. 1994 Nov-Dec;3(6):302-6.

Azione della melatonina:
Plasma melatonin concentrations in tumor-bearing rats killed at 3.00 h were suppressed by 35% when compared to the control animals killed at the same time.

Target:
Plasma melatonin concentrations
Titolo: Differences between pulsatile or continuous exposure to melatonin on MCF-7 human breast cancer cell proliferation

Riferimento:
Cancer Lett. 1994 Sep 30;85(1):105-9.

Azione della melatonina:
Antiproliferative effect was obtained by sequential exposure to 10(-9) M/10(-11)M 12/12h melatonin, which mimics the physiological rhythm of serum melatonin concentration.

Target:
Physiological rhythm/serum melatonin concentration
Titolo: Melatonin modulates growth factor activity in MCF-7 human breast cancer cells

Riferimento:
J Pineal Res. 1994 Aug;17(1):25-32.

Azione della melatonina:
Melatonin(10(-9)M) may inhibit the action and/or release of growth stimulatory factors as well as stimulate the release of growth inhibitory factors.

Target:
Epidermal growth factor (EGF)
Titolo: Breast cancer mortality among female electrical workers in the United States

Riferimento:
J Natl Cancer Inst. 1994 Jun 15;86(12):921-5.

Azione della melatonina:
Exposure to extremely low-frequency electromagnetic fields reduces the production of melatonin.

Target:
ELF
Titolo: Diminished pineal function coincides with disturbed circadian endocrine rhythmicity in untreated primary cancer patients. Consequence of premature aging or of tumor growth?

Riferimento:
Ann N Y Acad Sci. 1994 May 31;719:502-25. Review.

Azione della melatonina:
No abstract available.

Target:
No abstract available.

A.I.A.N. - Modena

Melatonina

Anno: 1993

Anno: 1994

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