Neoplasie della mammella
Anno: 1985
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Titolo: [Melatonin]Riferimento:Presse Med. 1985 Sep 21;14(31):1659-63. Review.Azione della melatonina:Abnormal concentrations in melatonin secretion has demonstrated in diseases as breast cancer.Target:Mlt/biological marker
Anno: 1986
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Riferimento:Chronobiologia. 1986 Apr-Jun;13(2):123-8Azione della melatonina:Administration time of melatonin is an indispensable complement to dosing, notably when effects upon tumorigenesis are involved.Target:Mlt daily injections
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Riferimento:J Neural Transm Suppl. 1986;21:433-49.Azione della melatonina:Physiological concentrations of mlt has inhibitory effects on MCF-7 cancer cell growth in culture.Target:Mlt/estradiol/ prolactin
Anno: 1987
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Riferimento:Eur J Cancer Clin Oncol. 1987 Jul;23(7):949-57.Azione della melatonina:The oncological patients showed higher mean melatonin serum levels than the control subjects. Mlt values were lower in patients with solid tumours who had metastases. Chemotherapy caused a decre- ase. Surgery was followed by a fall in melatonin in patients without metastases.Target:Mlt/oncological patients
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Titolo: Correlation between changes in prolactin and melatonin serum levels after radical mastectomyRiferimento:Tumori. 1987 Jun 30;73(3):263-7.Azione della melatonina:MLT serum values were significantly higher in patients than in controls. Radical mastectomy influences PRL and MLT secretions.Target:Prolactin (PRL) Melatonin (MLT)
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Riferimento:Crit Rev Clin Lab Sci. 1987;25(3):231-53. Review.Azione della melatonina:Great decline in the elevated melatonin level of oncological patients following institution of chemotherapy.Target:Mlt induce mitotic arrest
Anno: 1988
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Riferimento:Med Hypotheses. 1988 Dec;27(4):303-11.Azione della melatonina:Hypothalamic-pituitary axis could be significant in the aetiology of breast cancer as high prolactin and melatonin levels may be protective.Target:Hypothyroidism
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Riferimento:Cancer Res. 1988 Nov 1;48(21):6121-6.Azione della melatonina:Melatonin (10(-9) M; 10(-11) M) exerts a direct but reversible, antiproliferative effect on MCF-7 cell growth in culture.Target:Ultrastructural features
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Riferimento:Cancer. 1988 Aug 1;62(3):494-9.Azione della melatonina:The beta-endorphin/melatonin ratio was higher than 2 in normal subjects and in cancer patients without metastases, whereas was lower than 2 in all patients with metastases.Target:Pineal and opioid system
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Riferimento:Tumori. 1988 Jun 30;74(3):339-45.Azione della melatonina:Patients (75%) whose mlt enhanced after chemotherapy had an objective regression.Target:Mlt as a predictor