Anno: 1998

• Titolo: Flight attendants, breast cancer, and melatonin
  Riferimento:

  Lancet. 1998 Oct 24;352(9137):1388-9.
  Azione della melatonina:

  No abstract available.
  Target:

  No abstract available.
• Titolo: Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus aloe vera in untreatable advanced solid neoplasms
  Riferimento:

  Nat Immun. 1998;16(1):27-33.
  Azione della melatonina:

  Natural cancer therapy with MLT (20 mg/day orally in the dark period) plus A. vera extracts may produce some therapeutic benefits.
  Target:

  MLT plus Aloe vera.
• Titolo: Melatonin attenuates hydrogen peroxide toxicity in MCF7 cells only at pharmacological concentrations
  Riferimento:

  Biochem Biophys Res Commun. 1998 Sep 29;250(3):602-5.
  Azione della melatonina:

  Melatonin is an excellent oxygen radical scavenger at 10(-5) and 10(-4) M concentrations.
  Target:

  Oxygen radical scavenger.
• Titolo: Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells
  Riferimento:

  Cancer Res. 1998 Oct 1;58(19):4383-90.
  Azione della melatonina:

  Pretreatment of MCF-7 cells with 1 nM melatonin increased the response of tumoral cells to the antiinvasive effects.
  Target:

  Anti-invasive actions.
• Titolo: Reduced cancer incidence among the blind
  Riferimento:

  Epidemiology. 1998 Sep;9(5):490-4.
  Azione della melatonina:

  Blind people have a lower cancer incidence, although other explanations than the higher melatonin exposure must also be considered.
  Target:

  Totally blind people.
• Titolo: Breast cancer in female flight attendants
  Riferimento:

  Lancet. 1998 Aug 22;352(9128):626.
  Azione della melatonina:

  No abstract available.
  Target:

  No abstract available.
• Titolo: Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors
  Riferimento:

  Mol Cell Endocrinol. 1998 Jun 25;141(1-2):53-64.
  Azione della melatonina:

  Melatonin and EGF transactivate the ER, making the ER refractory to activation by estradiol.
  Target:

  Estrogen receptor (ER), epidermal growth factor (EGF).
• Titolo: "Melatonin replacement therapy" for postmenopausal women: is it justified?
  Riferimento:

  Menopause. 1998 Spring;5(1):60-4. Review.
  Azione della melatonina:

  Melatonin might be implicated in menopause-associated processes such as breast cancer.
  Target:

  Melatonin replacement therapy.
• Titolo: Dehydroepiandrosterone sulfate (DHEAS) secretion in early and advanced solid neoplasms: selective deficiency in metastatic disease
  Riferimento:

  Int J Biol Markers. 1998 Jul-Sep;13(3):154-7.
  Azione della melatonina:

  Studies evaluating circadian DHEAS secretion in relation in that of the pineal hormone MLT.
  Target:

  Dehydroepiandrosteronesulfate (DHEAS).
• Titolo: A sequential treatment regimen with melatonin and alA sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cellsl-trans retinoic acid induces apoptosis in MCF-7 tumour cells
  Riferimento:

  Br J Cancer. 1998 Jun;77(12):2129-37.
  Azione della melatonina:

  Melatonin (10(-9) M)and atRA (10(-9) M) should be considered for preclinical and clinical evaluation against ER-positive human breast cancer.
  Target:

  Oestrogen receptor (ER), all-trans retinoic acid (atRA).