Neoplasie della mammella
Anno: 2008
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1418-23.Azione della melatonina:Exposure to light at night has implications for the risk of breast cancer in postmenopausal women.Target:6-sulfatoxymelatonin.
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Titolo: Physiological effects of melatonin: role of melatonin receptors and signal transduction pathwaysRiferimento:Prog Neurobiol. 2008 Jul;85(3):335-53.Azione della melatonina:Alterations in melatonin receptor expression as well as changes in endogenous melatonin production have been shown in circadian rhythm sleep disorders, Alzheimer's and Parkinson's diseases, glaucoma, depressive disorder, breast and prostate cancer, hepatoma and melanoma.Target:Membrane MT1 and MT2 receptors,quinone reducta-se 2, calmodulin, calreti-culin and tubulin.
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Riferimento:J Pineal Res. 2008 Apr;44(3):307-15.Azione della melatonina:Melatonin administration (2 mg/kg BW/day) increased the BT rhythm amplitude and phase stability, reduced tumor weight and prevented intraperitoneal dissemination.Target:Body Temperature (BT)
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Riferimento:J Pineal Res. 2008 Aug;45(1):86-92.Azione della melatonina:Melatonin, at physiologic concentrations, modulates the inhibition of sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) activity.Target:Sulfatase (STS) 17beta-HSD1
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Riferimento:Mol Cell Biochem. 2008 Dec;319(1-2):175-80.Azione della melatonina:Supplementation of diet with lycopene with melatonin provided antioxidant defense with strong chemo preventive activity against DMBA-induced mammary tumors.Target:7,12-dimethylbenz(a) anthracene (DMBA)
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Riferimento:J Pineal Res. 2008 Nov;45(4):476-88.Azione della melatonina:The growth-inhibitory actions of melatonin are mediated via both G(alphai2) and G(alphaq) proteins.Target:MT1 G protein-coupled receptor.
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Riferimento:Biochem Pharmacol. 2008 Feb 1;75(3):713-24.Azione della melatonina:Indole-3-carbinol (I3C)induces a G1 cell cycle arrest of human breast cancer cells,whereas both tryptophol and melatonin failed to induce the cell cycle arrest.Target:Indole-3-carbinol (I3C)
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Riferimento:Toxicol Lett. 2008 Oct 1;181(3):190-5.Azione della melatonina:Melatonin increases Cd-induced expression of MT-2A, which is considered to protect against Cd toxicity, modulating MTs synthesis.Target:Cadmium (Cd) Metallothioneins (MTs)
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Riferimento:Neuro Endocrinol Lett. 2008 Dec;29(6):857-66.Azione della melatonina:Use of MDB as the first line therapy, in a patient which had not been debilitated by the effects of chemo-and radiotherapy, contributed greatly to the final outcome.Target:(MDB)
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Riferimento:Med Hypotheses. 2008 Dec;71(6):862-7.Azione della melatonina:Portion of the survival benefit of Aromatase inhibtors (AIs) is due to their indirect effect on melatonin, not just their direct effect on estrogen.Target:Aromatase inhibitors (AIs)