Neoplasie della mammella
Anno: 2009
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Riferimento:Free Radic Biol Med. 2009 Jan 15;46(2):253-62.Azione della melatonina:NQO2 is a newly discovered binding site (MT3) of melatonin, indicating that it could be a novel target for prevention of breast cancer initiation.Target:Quinone oxidoreductase 2 (NQO2).
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Riferimento:J Pineal Res. 2009 Aug;47(1):23-31.Azione della melatonina:Treatment of MCF-7 breast cancer cells with melatonin counteracted the increase induced by estradiol almost completely.Target:Membrane-bound receptor MT1.
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Riferimento:Breast Cancer Res Treat. 2009 Nov;118(2):293-305.Azione della melatonina:Amplification of the MT1gene in some breast tumors and an inverse correlation with ERalpha, PR and MT1 G protein-coupled melatonin receptor.Target:Estrogen receptor alpha (Eralpha), progesterone receptor (PR).
Anno: 2010
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Riferimento:Curr Cancer Drug Targets. 2010 May;10(3):279-86.Azione della melatonina:Mlt counteracted the stimulatory effects of estrone sulfate and exert its antitumoral effects by down-re-gulating the sulfatase pathway of the tumoral tissue.Target:Sulfatase-inhibitory properties of melatonin.
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):729-37.Azione della melatonina:Positive association between 6-sulphatoxymelatonin (aMT6s) and risk of breast cancer.Target:aMT6s
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Titolo: Global breast cancer seasonalityRiferimento:Breast Cancer Res Treat. 2010 Aug;123(1):233-43.Azione della melatonina:Breast cancer is consistently diagnosed more often in spring. Its mechanism may depend upon seasonal sunlight mediation of vitamin D and seasonal mediation of nocturnal melatonin peak level and duration.Target:Latitude-dependent breast cancer seasonality.
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Riferimento:Scand J Work Environ Health. 2010 Mar;36(2):163-79.Azione della melatonina:The multilevel endocrine changes caused by circadian disruption with melatonin suppression (LAN) lead to the oncogenic targeting of the endocrine-responsive breast in women and possibly the prostate.Target:LAN
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Riferimento:Cell Cycle. 2010 Jan 1;9(1):188-97.Azione della melatonina:The combined treatment with metformin + melatoni (2 mg/L in drinking water during the night time) significantly suppressed Ehrlich tumor growth.Target:Biguanide metformin.
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Riferimento:Breast Cancer Res. 2010;12(6):R107.Azione della melatonina:Mlt (10-9M) exerts an inhibitory effect on breast cancer cell invasion through down-regulation of the p38, and inhibition of MMP-2 and MMP-9.Target:Proteinase activity of MMP-2 and MMP-9.
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Riferimento:Bioelectromagnetics. 2010 Apr;31(3):237-45.Azione della melatonina:In breast cancer cells transfected with MT1 exposed to 1.2 microT of the 50 Hz EMF, the expression of p53 and c-myc increased significantly after melatonin treatment.Target:Electromagnetic fields (EMFs)