Neoplasie della mammella
Anno: 2009
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Riferimento:J Pineal Res. 2009 Mar;46(2):172-80.Azione della melatonina:Two distinct apoptotic processes are triggered by melatonin(1 nM), an early, TGFbeta1 and caspase-independent response, and a late TGFbeta1-dependent process in which activated-caspase-7.Target:Transforming growth factor beta 1 (TGFbeta1)
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Riferimento:Integr Cancer Ther. 2009 Dec;8(4):347-53.Azione della melatonina:Melatonin's anticancer effects in vivo involves inhibition of linoleic acid(LA)uptake and its metabolism to mitogenically active 13-hydroxyoctadecadienoic acid (13-HODE).Target:LA 13-HODE
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Titolo: Urinary melatonin levels and postmenopausal breast cancer risk in the Nurses' Health Study cohortRiferimento:Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):74-9.Azione della melatonina:An increased concentration of urinary aMT6s was associated with a lower risk of breast cancer.Target:6-sulfatoxymelatonin (aMT6s).
Anno: 2010
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Riferimento:Cell Cycle. 2010 Jan 1;9(1):188-97.Azione della melatonina:The combined treatment with metformin + melatoni (2 mg/L in drinking water during the night time) significantly suppressed Ehrlich tumor growth.Target:Biguanide metformin.
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Riferimento:Breast Cancer Res. 2010;12(6):R107.Azione della melatonina:Mlt (10-9M) exerts an inhibitory effect on breast cancer cell invasion through down-regulation of the p38, and inhibition of MMP-2 and MMP-9.Target:Proteinase activity of MMP-2 and MMP-9.
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Riferimento:Bioelectromagnetics. 2010 Apr;31(3):237-45.Azione della melatonina:In breast cancer cells transfected with MT1 exposed to 1.2 microT of the 50 Hz EMF, the expression of p53 and c-myc increased significantly after melatonin treatment.Target:Electromagnetic fields (EMFs)
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Titolo: [Shift work and breast cancer]Riferimento:G Ital Med Lav Ergon. 2010 Oct-Dec;32(4):454-7.Azione della melatonina:Internal disruption of biological circadian rhythms and clock genes, melatonin suppression through light by night, sleep deprivation and breast cancer risk in women shift workers.Target:LAN
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Riferimento:J Pineal Res. 2010 Oct;49(3):210-21.Azione della melatonina:At a dosage of 25 mg/kg/day, S23478-1 is more efficacious than melatonin at inducing regression in rat mammary tumors.Target:MT1/MT2 melatonin receptor agonists,S23478-1.
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Riferimento:Steroids. 2010 Dec;75(12):944-51.Azione della melatonina:Physiologic concentrations of MLT inhibit the individual and combined transcriptional activity of ERalpha by RORalpha1 and E(2).Target:RORalpha1/E(2).
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Riferimento:Curr Cancer Drug Targets. 2010 May;10(3):279-86.Azione della melatonina:Mlt counteracted the stimulatory effects of estrone sulfate and exert its antitumoral effects by down-re-gulating the sulfatase pathway of the tumoral tissue.Target:Sulfatase-inhibitory properties of melatonin.