Neoplasie della mammella
Anno: 2010
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Titolo: Global breast cancer seasonalityRiferimento:Breast Cancer Res Treat. 2010 Aug;123(1):233-43.Azione della melatonina:Breast cancer is consistently diagnosed more often in spring. Its mechanism may depend upon seasonal sunlight mediation of vitamin D and seasonal mediation of nocturnal melatonin peak level and duration.Target:Latitude-dependent breast cancer seasonality.
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Riferimento:Scand J Work Environ Health. 2010 Mar;36(2):163-79.Azione della melatonina:The multilevel endocrine changes caused by circadian disruption with melatonin suppression (LAN) lead to the oncogenic targeting of the endocrine-responsive breast in women and possibly the prostate.Target:LAN
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Riferimento:Cell Cycle. 2010 Jan 1;9(1):188-97.Azione della melatonina:The combined treatment with metformin + melatoni (2 mg/L in drinking water during the night time) significantly suppressed Ehrlich tumor growth.Target:Biguanide metformin.
Anno: 2011
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Riferimento:J Pineal Res. 2011 Mar;50(2):150-8.Azione della melatonina:Cytostatic effects triggered by melatonin and D3 are likely related to a complex TGFβ-1-dependent mechanism, involving down-regulation of both MDM2 and Akt-phosphorylation.Target:p53/MDM2 ratio.
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Riferimento:EPMA J. 2011 Dec;2(4):351-6.Azione della melatonina:Shift workers suffer from a disruption of the sleep-wake rhythm, insomnia and a lack of melatonin. These factors might trigger the development of breast cancer in female shift workers.Target:Shift work
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Riferimento:Breast Cancer Res Treat. 2011 May;127(1):91-8.Azione della melatonina:Abstract Mammary tumor growth is associated with old age and diminished levels of MLT and MT1 receptor during old age, resulting in reduced sensitivity to exogenous MLT.Target:MLT and its MT1 receptor.
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Titolo: Melatonin and associated signaling pathways that control normal breast epithelium and breast cancerRiferimento:J Mammary Gland Biol Neoplasia. 2011 Sep;16(3):235-45.Azione della melatonina:Light-at-night (LAN) induced circadian disruption of the nocturnal melatonin signal activates human breast cancer growth.Target:MT(1)melatonin receptors Estrogen receptor-positive (Erα+), G(αi2) signaling.
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Riferimento:J Pineal Res. 2011 Oct;51(3):345-52.Azione della melatonina:MLT may modulate miRNA and gene expression as an anticancer mechanism in MCF-7 human breast cancer cells.Target:MicroRNAs (miRNAs).
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Riferimento:J Pineal Res. 2011 Oct;51(3):259-69.Azione della melatonina:Down-regulation of 13-HODE reduces the activation of growth factor pathways supporting cell proliferation and survival.Target:3-hydroxyoctadecadie-noic acid (13-HODE).
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Riferimento:J Recept Signal Transduct Res. 2011 Apr;31(2):180-7.Azione della melatonina:The low expression of CYP1A1 or CYP1A2 in breast cancer specimens suggested that melatonin might be involved in cell cycle arrest.Target:CYP1A1/1A2, SULT1A1/1A3/1E1, cyclin D1.