Neoplasie della mammella
Anno: 2012
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Titolo: A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkersRiferimento:Cancer Causes Control. 2012 Apr;23(4):609-16.Azione della melatonina:Effects of melatonin supplementation (3 mg oral melatonin, daily for 4 months) in postmenopausal breast cancer survivors.Target:Estradiol-lowering effects of melatonin.
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Riferimento:Expert Opin Investig Drugs. 2012 Jun;21(6):819-31.Azione della melatonina:Melatonin could be an excellent adjuvant with the drugs currently used for breast cancer prevention.Target:Selective estrogen receptor/enzyme modulators
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Riferimento:Recent Pat Endocr Metab Immune Drug Discov. 2012 May;6(2):108-16. Review.Azione della melatonina:Based on its Selective Estrogen Receptor Modulator [SERM) and Selective Estrogen Enzyme Modulator (SEEM) properties. Its nocturnal suppression by light-at-night (LAN) has been considered a risk-factor for breast cancer.Target:Inhibiting activity of P450 aromatase.
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Riferimento:Scand J Work Environ Health. 2012 Jul 1;38(4):380-90.Azione della melatonina:Elevations in risk of breast cancer after about 20 years working night shift. Accelerated tumor growth by suppression of melatonin secretion.Target:Shift work carcinogenic to humans (group 2A).
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Riferimento:J Pineal Res. 2012 Aug;53(1):77-90.Azione della melatonina:Inhibits cell proliferation and induces apoptosis in MDA-MB-361 breast cancer cells in vitro by simultaneously suppressing the COX-2/PGE2, p300/NF-κB and PI3K/Akt/signaling and activating the Apaf-1/ caspase-dependent apoptotic pathway.Target:Mlt 10(-3)M
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2012 Apr;21(4):609-18.Azione della melatonina:Night shift work may disrupt the normal nocturnal rise in melatonin, resulting in increased breast cancer risk.Target:Reduced 6-sulfatoxymelatonin levels during night work and daytime sleep.
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Riferimento:J Recept Signal Transduct Res. 2012 Dec;32(6):290-7.Azione della melatonina:EMR increase the risk of breast cancer suppressing the production of melatonin which may modulate breast cancer through enhanced oxidative stress and Ca(2+) influx in cell lines.Target:Electromagnetic radiation (EMR)
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Riferimento:Sleep Med Rev. 2012 Nov 5.Azione della melatonina:Melatonin suppression increased breast cancer risk, in night and rotating female shift workers.Target:Shift work
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Riferimento:BMJ Open. 2012 Jan 21;2(1).Azione della melatonina:Inverse relationship between aMTs-6(6-sulfatoxymelatonin) and oestradiol was suggested in the winter.Target:Long-term shift work as a probable carcinogen.
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Riferimento:Klin Onkol. 2012;25(5):359-63.Azione della melatonina:Melatonin ( 4 times a week,20 μg/ml of drinking water) significantly reduced tumor volume in comparison with control animals.Target:Chemoprevention