Neoplasie della mammella
Anno: 2012
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Riferimento:Klin Onkol. 2012;25(5):359-63.Azione della melatonina:Melatonin ( 4 times a week,20 μg/ml of drinking water) significantly reduced tumor volume in comparison with control animals.Target:Chemoprevention
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Riferimento:BMJ Open. 2012 Jan 11;2(1).Azione della melatonina:The effect of melatonin in a breast cancer population with the above-mentioned indications has not yet been studied.Target:Clock-gene, PER3.
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Riferimento:Am J Epidemiol. 2012 Nov 1;176(9):760-3.Azione della melatonina:Direct oncostatic properties of melatonin in shift-work-cancer association.Target:Night-shift work
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Titolo: Melatonin suppresses aromatase expression and activity in breast cancer associated fibroblastsRiferimento:Breast Cancer Res Treat. 2012 Apr;132(2):765-71.Azione della melatonina:MLT inhibits estrogen production in breast adipose fibroblasts (BAFs) by inhibiting transcription of the CYP19A1 gene.Target:Physiological doses of MLT.
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Riferimento:Cell Mol Life Sci. 2012 Sep 25.Azione della melatonina:Melatonin acts at different mechanisms of action, nvolving apoptosis activation, inhibition of proliferation, and cell differentiation.Target:Melatonin acts at different physiological levels.
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Riferimento:J Pineal Res. 2012 Aug 16.Azione della melatonina:Melatonin(1mm) play a role in the paracrine interactions between malignant epithelial cells and proximal endothelial cells through a downregulatory action on VEGF expression in human breast cancer cells, as well as decreasing tumoral angiogenesis.Target:Vascular endothelial growth factor (VEGF)
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Titolo: Melatonin interferes in the desmoplastic reaction in breast cancer by regulating cytokine productionRiferimento:J Pineal Res. 2012 Apr;52(3):282-90.Azione della melatonina:One millimolar melatonin induced a reduction in TNF-α, IL-6, and IL-11 mRNA expression in MCF-7 and 3T3-L1 cells.Target:Aromatase enzyme,tumor necrosis factor (TNF)-α, interleukin (IL)-11 and interleukin (IL)-6.
Anno: 2013
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Riferimento:BMC Cell Biol. 2013 Jan 7;14:1.Azione della melatonina:Melatonin enhance DNA repair capacity by affecting several key genes involved in DNA damage responsive pathways.Target:DNA repair capacity
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Riferimento:Breast Cancer Res Treat. 2013 Feb;137(3):677-87.Azione della melatonina:Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.Target:TNBC