Neoplasie della mammella
Anno: 1996
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Riferimento:Bioelectromagnetics. 1996;17(5):396-405.Azione della melatonina:Effects of light and electromagnetic fields (EMFs) could have implications for long-term risk of breast cancer, peak levels may be consistent with those thought to suppress melatonin.Target:Light and electromagnetic fields (EMFs)
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Titolo: Modulation of the length of the cell cycle time of MCF-7 human breast cancer cells by melatoninRiferimento:Life Sci. 1996;58(9):811-6.Azione della melatonina:Melatonin,(10(-9)M) added to the culture medium, increased the duration of the cell cycle of human breast cancer cells, delaying the entry into mitosis.Target:Melatonin inhibitory effect
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Riferimento:Br J Cancer. 1996 Nov;74(9):1466-8.Azione della melatonina:Combination with Tamoxifene plus Melatonin (20 mg day) may have some benefit in untreatable metastatic solid tumour patients.Target:Melatonin/tamoxifen
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Titolo: Melatonin in human breast cancer tissue: association with nuclear grade and estrogen receptor statusRiferimento:Lab Invest. 1996 Oct;75(4):557-61.Azione della melatonina:ExogenousMLT may influence nuclear grade and/or estrogen receptor activity in breast cancer patients.Target:Nuclear grade/melatonin
Anno: 1997
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Riferimento:J Pineal Res. 1997 Nov;23(4):169-75.Azione della melatonina:Melatonin [(10(-9) M or10(-10) M) for 2 and 5 days] induced very slight alterations in microtubule organization of all cell lines studied.Target:Cytoskeleton.
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Riferimento:Pharmacol Toxicol. 1997 Dec;81(6):265-70.Azione della melatonina:Seasonal variation in the development and growth of DMBA-induced breast cancer as the seasonal variation in pineal melatonin production.Target:Circannual rhythms.
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Riferimento:Wien Klin Wochenschr. 1997 Oct 3;109(18):722-9. Review. German.Azione della melatonina:Yet unknown chemical structure are capable of inhibiting in vitro cell lines resistant to melatonin.Target:Progressive decline of pineal melatonin secretion.
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Riferimento:J Pineal Res. 1997 Sep;23(2):53-8.Azione della melatonina:Decreased pineal melatonin secretion in breast cancer patients as well as an inverse relationship with tumor-size.Target:6-sulphatoxymelatonin (aMT6s)
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Riferimento:Cancer Res. 1997 May 15;57(10):1909-14.Azione della melatonina:10 microM L-buthionine-[S,R]-sulfoximine(L-BSO) blocks the oncostatic action of 1nM melatonin, glutathione(1microM) is required for melatonin action.Target:Glutathione.
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Riferimento:J Pineal Res. 1997 May;22(4):184-202. Review.Azione della melatonina:Melatonin could indeed be considered a physiological anticancer substance.Target:Antioxidative functions, indirect immunostimulatory effects.