Neuroendocrine tumors of larynx--two case reports and literature review

Coll Antropol. 2012 Nov;36 Suppl 2:173-8.
Cari? T, Bili? M, Bili? LK, Prgomet D, Kovaci? J, Grahovac IT, Hutinec Z.
Coll Antropol. 2012 Nov;36 Suppl 2:173-8.
OctreoScan è uno strumento utile per la diagnostica e il follow-up dei pazienti con tumori neuroendocrini (NET) della laringe ed è predittivo per l'efficacia della terapia con octreotide.
Octreoscan/tumori neuroendocrini della laringe.

Neuroendocrine tumors (NET) of the larynx are rare and heterogenous group, with much confusion about nature and classification of these neoplasms in the past. Diagnosis is based primarily on light microscopy and confirmed by immunohistochemistry and electron microscopy. A classification in 4 different types; paraganglioma, typical carcinoid, atypical carcinoid and small cell neuroendocrine carcinoma (SCNC) is a current consensus. Thorough diagnostic and a proper classification of neuroendocrine neoplasms are of paramount importance--prognosis and treatment differ significantly. We present two cases: 63-year old patient with SCNC of the larynx and a 53-year old patient with atypical carcinoid of the larynx. OctreoScan is useful tools for diagnostics and follow up of the patients and it is predictive for effectiveness of octreotide therapy.