ABSTRACT
BACKGROUND:
There are limited studies on the effects of drugs that modulate epigenetic regulation for head and neck squamous cell carcinoma (HNSCC). This study determined the effect of valproic acid (VPA) on HNSCC.
METHODS:
Growth inhibition effects of VPA alone or in combination with 5-aza-2'deoxycytidine (5-aza-dC) or all-trans retinoic acid (ATRA) was evaluated with MTT and clonogenic assays on 5 HNSCC cell lines. The mechanism of growth inhibition was investigated by looking at markers of terminal differentiation and senescence.
RESULTS:
Growth inhibition profiles of HNSCC cell lines varied in response to VPA. Inhibition of clonogenic survival in response to VPA was associated with an upregulation of p21, expression of terminal differentiation markers, and cellular senescence. Notably, a combination treatment of 5-Aza-dC-VPA-ATRA enhanced growth inhibition in cells resistant to VPA. CONCLUSION: VPA is a potent inhibitor of proliferation in some HNSCC cell lines, and may be used to treat HNSCC.
Valproic acid: growth inhibition of head and neck cancer by induction of terminal differentiation and senescence
Riferimento:
Head Neck. 2012 Mar;34(3):344-53.
Autori:
Gan CP, Hamid S, Hor SY, Zain RB, Ismail SM, Wan Mustafa WM, Teo SH, Saunders N, Cheong SC.
Fonte:
Oral Cancer Research Team, Cancer Research Initiatives Foundation, Second Floor, Outpatient Centre, Sime Darby Medical Centre, 47500 Subang Jaya, Selangor, Malaysia.
Anno:
2012
Azione:
Questo studio ha determinato l'effetto dell' acido valproico (VPA) in combinazione con l'acido all trans retinoico (ATRA) sul carcinoma a cellule squamose della testa e del collo (HNSCC). VPA è un potente inibitore della proliferazione in alcune linee cellulari di questo tipo di carcinoma.
Target:
VPA-ATRA/carcinoma a cellule squamose della testa e del collo.
Sostanze: