Riferimento:
Semin Nephrol. 2012 May;32(3):287-94.
Autori:
Xu Q, Kopp JB.
Fonte:
Semin Nephrol. 2012 May;32(3):287-94.
Anno:
2012
Azione:
Le interazioni tra fattore di crescita trasformante-β (TGF-β) e retinoidi, derivati della vitamina A, sono molto complessi e dipendono dalle impostazioni tissutali, cellulari, e molecolari.
Target:
TGF-β, Retinoidi/impostazioni biologiche.
ABSTRACT
Transforming growth factor-β (TGF-β) isoforms are profibrotic cytokines, par excellence, and have complex multifunctional effects on many systems, depending on the biologic setting. Retinoids are vitamin A derivatives that also have diverse effects in development, physiology, and disease. The interactions between these classes of molecules are, not surprisingly, highly complex and are dependent on the tissue, cellular, and molecular settings.
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