ABSTRACT
All-trans retinoic acid and derivatives (retinoids) are promising agents in the management of certain hematologic malignancies and solid tumors, including breast cancer. Retinoids are endowed with anti-proliferative, cyto-differentiating and apoptotic effects that are largely mediated by activation of the nuclear hormone retinoic acid receptors RARα, RARβ and RARγ. These are ligand-dependent transcriptional factors controlling the expression of numerous genes. The relative importance of each receptor subtype for the anti-tumor activity of retinoids is largely unknown. Clarification of this point is of fundamental importance for the rational design of retinoid-based therapeutic approaches aimed at controlling a heterogeneous type of tumors, like breast cancer.
Retinoids and breast cancer: new clues to increase their activity and selectivity
Riferimento:
Breast Cancer Res. 2012 Sep 4;14(5):111.
Autori:
Garattini E, Paroni G, Terao M. enrico.garattini@marionegri.it.
Fonte:
Breast Cancer Res. 2012 Sep 4;14(5):111.
Anno:
2012
Azione:
L'acido all-trans retinoico e derivati (retinoidi) sono agenti promettenti nella gestione di alcune neoplasie ematologiche e tumori solidi, tra cui il cancro al seno. I retinoidi sono dotati di effetti anti-proliferativi, cito-differenzianti ed apoptotici.
Target:
Retinoidi/neoplasie ematologiche, cancro al seno.
Sostanze: