Neoplasie della mammella

Neoplasie della mammella

Exercise-induced stress enhances mammary tumor growth in rats: beneficial effect of the hormone melatonin

Mol Cell Biochem. 2007 Jan;294(1-2):19-24.
Sáez Mdel C, Barriga C, García JJ, Rodríguez AB, Ortega E.
Intense exercise-induced stress enhances mammary carcinogenesis through the involvement of adrenaline and prolactin, also confirmed a role of melatonin as a therapeutic aid against breast cancer in general.
"Anti-stress" role of Mlt.

Complementary/Alternative therapies for the treatment of breast cancer. A systematic review of randomized clinical trials and a critique of current terminology

Breast J. 2006 Nov-Dec;12(6):526-30.
Ernst E, Schmidt K, Baum M.
Systematic review of RCTs involving breast cancer patients treated with ACCs, survival, parameters indicative of tumor burden, disease progression, cancer recurrence, and cancer cure. Encouraging but not fully convincing results emerged for melatonin.
Randomized clinical trials (RCTs) Alternative cancer cures (ACCs)

Associations among salivary cortisol, melatonin, catecholamines, sleep quality and stress in women with breast cancer and healthy controls

J Behav Med. 2007 Feb;30(1):45-58.
Carlson LE, Campbell TS, Garland SN, Grossman P.
Forty percent of the women with breast cancer had stage 2 disease and they were an average of 1.36years post-diagnosis. Women with breast cancer had significantly higher levels of disturbance on all the psychological indices.
Dysregulations across systems in breast cancer patients.

Human melatonin MT1 receptor induction by valproic acid and its effects in combination with melatonin on MCF-7 breast cancer cell proliferation

Eur J Pharmacol. 2007 Mar 29;560(1):17-22.
Jawed S, Kim B, Ottenhof T, Brown GM, Werstiuk ES, Niles LP.
A combination of valproic acid (0.5, 1.0 or 5 mM) and melatonin (1 or 10 nM) suggests that a similar approach may be beneficial in breast cancer.
MT1 Mlt receptor mRNA.

Effects of MT1 melatonin receptor overexpression on the aromatase-suppressive effect of melatonin in MCF-7 human breast cancer cells

Oncol Rep. 2007 Apr;17(4):947-53.
González A, Martínez-Campa C, Mediavilla MD, Alonso-González C, Sánchez-Mateos S, Hill SM, Sánchez-Barceló EJ, Cos S.
Melatonin inhibits both aromatase activity as a selective estrogen enzyme modulator. 20% at 1 nM; 40% at 10 microM Mlt concentrations.
MT1 melatonin receptor.

Melatonin prevents the estrogenic effects of subchronic administration of cadmium on mice mammary glands and uterus

J Pineal Res. 2007 Apr;42(4):403-10.
Alonso-González C, González A, Mazarrasa O, Güezmes A, Sánchez-Mateos S, Martínez-Campa C, Cos S, Sánchez-Barceló EJ, Mediavilla MD.
Female mice were treated with CdCl(2) (2-3 mg/kg, i.p.), melatonin (10 microg/mL in drinking water), CdCl(2) + melatonin, or diluents. The effects of Cd are partially inhibited by melatonin.
Cd-induced carcinogenicity.

Pagine

Abbonamento a RSS - Neoplasie della mammella