Oscillation of clock and clock controlled genes induced by serum shock in human breast epithelial and breast cancer cells: regulation by melatonin

Breast Cancer (Auckl). 2012;6:137-50.
Xiang S, Mao L, Duplessis T, Yuan L, Dauchy R, Dauchy E, Blask DE, Frasch T, Hill SM.
Melatonin administration following serum shock differentially suppressed or induced clock gene (Bmal1 and Per2) and CCG expression in MCF10A and MCF-7 cells.
Clock and clock-controlled genes (CCGs)

Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells

J Pineal Res. 2012 Aug 16.
Alvarez-García V, González A, Alonso-González C, Martínez-Campa C, Cos S.
Melatonin(1mm) play a role in the paracrine interactions between malignant epithelial cells and proximal endothelial cells through a downregulatory action on VEGF expression in human breast cancer cells, as well as decreasing tumoral angiogenesis.
Vascular endothelial growth factor (VEGF)

Role of melatonin on electromagnetic radiation-induced oxidative stress and Ca(2+) signaling molecular pathways in breast cancer

J Recept Signal Transduct Res. 2012 Dec;32(6):290-7.
Nazıroğlu M, Tokat S, Demirci S.
EMR increase the risk of breast cancer suppressing the production of melatonin which may modulate breast cancer through enhanced oxidative stress and Ca(2+) influx in cell lines.
Electromagnetic radiation (EMR)

Expression of melatonin receptors in triple negative breast cancer (TNBC) in African American and Caucasian women: relation to survival

Breast Cancer Res Treat. 2013 Feb;137(3):677-87.
Oprea-Ilies G, Haus E, Sackett-Lundeen L, Liu Y, McLendon L, Busch R, Adams A, Cohen C.
Melatonin or a melatonin receptor agonist may be useful biologic additions in the treatment of some forms of triple negative human breast carcinoma.

Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation

Expert Opin Investig Drugs. 2012 Jun;21(6):819-31.
Sanchez-Barcelo EJ, Mediavilla MD, Alonso-Gonzalez C, Reiter RJ.
Melatonin could be an excellent adjuvant with the drugs currently used for breast cancer prevention.
Selective estrogen receptor/enzyme modulators


Abbonamento a RSS - Melatonina