Neoplasie della mammella
Anno: 2008
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Riferimento:Aviat Space Environ Med. 2007 Apr;78(4 Suppl):A26-37.
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Riferimento:J Natl Cancer Inst. 2008 Jun 18;100(12):898-905.Azione della melatonina:Statistically significant inverse association between melatonin levels, as measured in overnight morning urine, and invasive breast cancer risk in postmeno pausal women.Target:6-sulfatoxymelatonin.
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Riferimento:Carcinogenesis. 2008 Jun;29(6):1244-8.Azione della melatonina:Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors.Target:HumanTelomerase ReverseTranscriptase (hTERT)
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Riferimento:Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1418-23.Azione della melatonina:Exposure to light at night has implications for the risk of breast cancer in postmenopausal women.Target:6-sulfatoxymelatonin.
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Riferimento:Carcinogenesis. 2008 Jun;29(6):1244-8.Azione della melatonina:Sleep duration may influence breast cancer risk, possibly via its effect on melatonin levels.Target:6-sulfatoxymelatonin.
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Titolo: Physiological effects of melatonin: role of melatonin receptors and signal transduction pathwaysRiferimento:Prog Neurobiol. 2008 Jul;85(3):335-53.Azione della melatonina:Alterations in melatonin receptor expression as well as changes in endogenous melatonin production have been shown in circadian rhythm sleep disorders, Alzheimer's and Parkinson's diseases, glaucoma, depressive disorder, breast and prostate cancer, hepatoma and melanoma.Target:Membrane MT1 and MT2 receptors,quinone reducta-se 2, calmodulin, calreti-culin and tubulin.
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Riferimento:J Pineal Res. 2008 Apr;44(3):307-15.Azione della melatonina:Melatonin administration (2 mg/kg BW/day) increased the BT rhythm amplitude and phase stability, reduced tumor weight and prevented intraperitoneal dissemination.Target:Body Temperature (BT)
Anno: 2009
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Riferimento:Breast Cancer Res Treat. 2009 May;115(1):13-27.Azione della melatonina:The oncostatic properties of melatonin as they involve epigenetic mechanisms of cancer are reviewed.Target:Eralpha, aromatase, CYP19 histones,cyclin D1 LAN, PER2.
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Riferimento:Expert Rev Mol Med. 2009 Feb 5;11:e5.Azione della melatonina:Potential use of melatonin in breast cancer prevention and treatment.Target:Oestrogen-dependent, free-radical formation.
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Riferimento:Integr Cancer Ther. 2009 Dec;8(4):354-60.Azione della melatonina:The three major consequences of light at night are sleep deprivation, chronodisruption, and melatonin suppression.Target:LAN