Riferimento:
Carcinogenesis. 2008 Jun;29(6):1244-8.
Autori:
Martínez-Campa CM, Alonso-González C, Mediavilla MD, Cos S, González A, Sanchez-Barcelo EJ.
Fonte:
Department of Physiology and Pharmacology, School of Medicine, University of Cantabria, Cardenal Herrera Oria s/n, Santander, Spain.
Anno:
2008
Azione:
Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors.
Target:
HumanTelomerase ReverseTranscriptase (hTERT)
The goal was to evaluate whether melatonin (Mel) down-regulates hTERT expression induced by 17beta-estradiol (E(2)) or cadmium (Cd) in breast cancer cells.
We found that: (a) Mel inhibits E(2) or Cd-induced hTERT transcription in hTERT-Luc transfected MCF-7 cells, (b) Mel significantly reduces E(2)- and Cd-mediated hTERT transactivation triggered by ERalpha in transfected HeLa cells, (c) Mel inhibits hTERT expression induced by E(2) or Cd in MCF-7 cells. Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors or carcinogenesis by environmental or occupational exposure to xenoestrogens.
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