Leucemie Linfomi Mielomi

Leucemie Linfomi Mielomi

The clinical significance of melatonin serum determination in oncological patients and its correlations with GH and PRL blood levels

Eur J Cancer Clin Oncol. 1987 Jul;23(7):949-57.
Lissoni P, Bastone A, Sala R, Mauri R, Rovelli F, Viviani S, Bajetta E, Esposti D, Esposti G, di Bella L, et al.
The oncological patients showed significantly higher mean melatonin serum levels than the control subjects. Mean melatonin values were lower in patients with solid tumours who had metastases, than in cases without metastases. GH and PRL serum levels were similar to control subjects.

Intracellular metabolism of biogenic amines in paraneurons

Arch Histol Cytol. 1989;52 Suppl:69-74.
Hasegawa H, Kobayashi T, Inoue F, Ichiyama A.
Serotonin is one of the representative biogenic amines produced from tryptophan in the gastrointestinal tract as well as in the brain. The capacity to synthesize serotonin depends on the existence of tryptophan monooxygenase. The activity of tryptophan monooxygenase in paraneurons such as mastocytomas and enterochromaffin cells depends on available ferrous iron.
L-5HTP monooxygenase.

The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes

J Biol Chem. 1995 Mar 31;270(13):7037-40.
Steinhilber D, Brungs M, Werz O, Wiesenberg I, Danielsson C, Kahlen JP, Nayeri S, Schräder M, Carlberg C.
Melatonin is a natural ligand of RZR alpha and RZR beta, down-regulating the expression of 5-lipoxygenase about 5-fold in B-Lymphocytes.
Retinoid Z receptor (RZR alpha and beta).


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