Leucemie Linfomi Mielomi

Leucemie Linfomi Mielomi

Inhibition of proliferation and induction of apoptosis by melatonin in human myeloid HL-60 cells

J Pineal Res. 2007 Mar;42(2):131-8.
Rubio S, Estévez F, Cabrera J, Reiter RJ, Loro J, Quintana J.
Inhibiting progression from G(1) to S phase of the cell cycle and increasing apoptotic cell death.
Elevated cytochrome c release from mitochondria augmented caspase-3 and caspase-9 activities, regulation of Bax/Bcl-2 expression.

Can disturbances in the atmospheric electric field created by powerline corona ions disrupt melatonin production in the pineal gland?

J Pineal Res. 2008 Nov;45(4):341-50.
Henshaw DL, Ward JP, Matthews JC.
Highly protective of oxidative damage to the human hemopoietic system.
Disruption of nocturnal melatonin synthesis andrelated circadian rhythms by electric fields.

Chronic lymphocytic leukemia: long-lasting remission with combination of cyclophosphamide, somatostatin, bromocriptine, retinoids, melatonin, and ACTH

Cancer Biother Radiopharm. 2009 Jun;24(3):353-5.
Todisco M.
No patients had disease recurrence, and progression-free survival has not yet been reached (125, 121, 73, and 21 months, respectively).
Toxicity was absent, and patients underwent the treatment at home.

Melatonin exerts differential actions on X-ray radiation-induced apoptosis in normal mice splenocytes and Jurkat leukemia cells

J Pineal Res. 2009 Sep;47(2):147-55.
Jang SS, Kim WD, Park WY.
Enhances radiation-induced apoptosis in Jurkat leukemia cells, while reducing radiation-induced apoptosis in normal mice splenocytes.
Increase of Bcl-2 expression and a reduction of Bax/Bcl-2 ratio through a relative decrease of p53 mRNA and protein.

Protective effect of melatonin on oxaliplatin-induced apoptosis through sustained Mcl-1 expression and anti-oxidant action in renal carcinoma Caki cells

J Pineal Res. 2010 Oct;49(3):283-90.
Um HJ, Kwon TK.
Inhibited DNA damage-induced apoptosis and glutathione (GSH) depletion.
TNF-α, TRAIL, anti-Fas antibody or endoplasmic reticulum (ER).

Melatonin promotes puromycin-induced apoptosis with activation of caspase-3 and 5'-adenosine monophosphate-activated kinase-alpha in human leukemia HL-60 cells

J Pineal Res. 2011 May;50(4):367-73.
Koh W, Jeong SJ, Lee HJ, Ryu HG, Lee EO, Ahn KS, Bae H, Kim SH.
Significantly augmented the cytotoxicity of puro-mycin in HL-60 cells.
AMPK.phosphorylation of 5'-

Regulation of the expression of death receptors and their ligands by melatonin in haematological cancer cell lines and in leukaemia cells from patients

J Pineal Res. 2011 Apr;50(3):345-55.
Casado-Zapico S, Martín V, García-Santos G, Rodríguez-Blanco J, Sánchez-Sánchez AM, Luño E, Suárez C, García-Pedrero JM, Menendez ST, Antolín I, Rodriguez C.
Induction of cell death in several human malignant haematological cell lines through the activation of the extrinsic pathway of apoptosis.
Death receptors Fas, DR4 and DR5 and their ligands Fas L and TRAIL.


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